RC3H2 - ring finger and CCCH-type domains 2 Gene

Also Known as MNAB; RNF164

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54542

About RC3H2

Cytogenetic location: 9q33.2 Genomic coordinates (GRCh38): 9:122,844,556-122,905,359 (from NCBI)

This gene has 10 transcripts (splice variants), 206 orthologues and 5 paralogues. Ubiquitous expression in lymph node (RPKM 7.8), testis (RPKM 7.6) and 25 other tissues.

Summary

Enables nucleic acid binding activity and ubiquitin protein Ligase activity. Involved in protein polyubiquitination. Located in cell surface; intracellular membrane-bounded organelle; and membrane. [provided by Alliance of Genome Resources, Apr 2022]

RC3H2 Products (6)

mRNA Protein Name
NM_001100588.3 NP_001094058.1 roquin-2 isoform 1
NM_001354478.2 NP_001341407.1 roquin-2 isoform 3
NM_001354479.2 NP_001341408.1 roquin-2 isoform 4
NM_001354482.2 NP_001341411.1 roquin-2 isoform 5
NM_001354486.2 NP_001341415.1 roquin-2 isoform 6
NM_018835.5 NP_061323.2 roquin-2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
10938276 GOA
enables RNA stem-loop binding IDA
IDA: Inferred from direct assay
26249698 GOA
enables double-stranded RNA binding IDA
IDA: Inferred from direct assay
26489670 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
24448648 GOA
Biological Process GO Annotation Evidence References Source
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
26489670 GOA
involved in protein polyubiquitination IMP
IMP: Inferred from mutant phenotype
24448648 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
10938276 GOA
located in membrane IDA
IDA: Inferred from direct assay
10938276 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RC3H2 Protein Structure

zf-CCCH

zf-CCCH: Zinc finger C-x8-C-x5-C-x3-H type (and similar) (411 - 437)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1191 a.a.
Protein Preferred Names Protein Names

roquin-2

  • RING finger protein 164

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11778 RC3H2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21727 Rc3h2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28244 Rc3h2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus RC3H2 VGNC VGNC:64541
Bos taurus RC3H2 VGNC VGNC:33819
Macaca mulatta RC3H2 VGNC VGNC:76799
Mus musculus RC3H2 MGD MGI:2442789
Rattus norvegicus RC3H2 RGD RGD:1304833
Others RC3H2 NCBI