Cers3 - ceramide synthase 3 Gene

Also Known as T3L; Gm488; Lass3; mCerS3; 4930550L11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 545975

Summary

Enables sphingosine N-acyltransferase activity. Involved in ceramide biosynthetic process and cornification. Acts upstream of or within sphingolipid biosynthetic process. Located in endoplasmic reticulum. Is expressed in epidermis; epidermis stratum granulosum; epidermis stratum spinosum; and face skin. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 9. Orthologous to human CERS3 (ceramide synthase 3). [provided by Alliance of Genome Resources, Apr 2022]

Cers3 Products (1)

mRNA Protein Name
NM_001164201.1 NP_001157673.1 ceramide synthase 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables sphingosine N-acyltransferase activity IDA
IDA: Inferred from direct assay
16753040 MGI
Biological Process GO Annotation Evidence References Source
involved in ceramide biosynthetic process IDA
IDA: Inferred from direct assay
22038835 MGI
involved in cornification IMP
IMP: Inferred from mutant phenotype
22038835 MGI
involved in epidermis development IMP
IMP: Inferred from mutant phenotype
22038835 MGI
acts upstream of or within sphingolipid biosynthetic process IDA
IDA: Inferred from direct assay
16753040 MGI
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
22038835 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ceramide synthase 3

  • LAG1 homolog, ceramide synthase 3

  • LAG1 longevity assurance homolog 3

  • dihydroceramide synthase 3

  • longevity assurance homolog 3

  • related to TRH3

  • sphingosine N-acyltransferase CERS3

  • ultra-long-chain ceramide synthase CERS3

  • very-long-chain ceramide synt

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-146831S CER3-d9 99.00% Unkown
HY-RS02538 CERS3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-146831S1 CER3-d3 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cers3 NCBI NCBI:204219