Otud5 - OTU domain containing 5 Gene

Also Known as DUBA; Sfc7; DXImx46e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54644

Summary

Predicted to enable Lys48-specific Deubiquitinase activity; Lys63-specific Deubiquitinase activity; and thiol-dependent Deubiquitinase. Acts upstream of or within several processes, including alpha-beta T cell differentiation; negative regulation of interleukin-17 production; and regulation of T-helper 17 type immune response. Orthologous to human OTUD5 (OTU Deubiquitinase 5). [provided by Alliance of Genome Resources, Apr 2022]

Otud5 Products (3)

mRNA Protein Name
NM_001290536.1 NP_001277465.1 OTU domain-containing protein 5 isoform 1
NM_001290537.1 NP_001277466.1 OTU domain-containing protein 5 isoform 3
NM_138604.3 NP_613070.2 OTU domain-containing protein 5 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25470037 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within CD8-positive, alpha-beta T cell differentiation IMP
IMP: Inferred from mutant phenotype
25470037 MGI
acts upstream of or within T-helper 17 cell lineage commitment IMP
IMP: Inferred from mutant phenotype
25470037 MGI
acts upstream of or within interleukin-21 production IMP
IMP: Inferred from mutant phenotype
25470037 MGI
acts upstream of or within interleukin-9 production IMP
IMP: Inferred from mutant phenotype
25470037 MGI
acts upstream of or within negative regulation of interleukin-17 production IGI
IGI: Inferred from genetic interaction
25470037 MGI
acts upstream of or within negative regulation of interleukin-17 production IMP
IMP: Inferred from mutant phenotype
25470037 MGI
acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
25470037 MGI
acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
25470037 MGI
acts upstream of or within regulation of T-helper 17 type immune response IMP
IMP: Inferred from mutant phenotype
25470037 MGI
acts upstream of or within regulation of protein stability IMP
IMP: Inferred from mutant phenotype
25470037 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

OTU domain-containing protein 5

  • deubiquinating enzyme A

  • deubiquitinating enzyme A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09874 OTUD5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19225 Otud5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25714 Otud5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Otud5 NCBI NCBI:55593