Usp27x - ubiquitin specific peptidase 27, X chromosome Gene

Also Known as Sfc11; Usp27

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54651

Summary

Enables Lys48-specific Deubiquitinase activity; Lys63-specific Deubiquitinase activity; and thiol-dependent Deubiquitinase. Involved in positive regulation of apoptotic process; protein deubiquitination; and protein stabilization. Predicted to be located in cytoplasm and nucleus. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 105. Orthologous to human USP27X (ubiquitin specific peptidase 27 X-linked). [provided by Alliance of Genome Resources, Apr 2022]

Usp27x Products (1)

mRNA Protein Name
NM_019461.4 NP_062334.2 ubiquitin carboxyl-terminal hydrolase 27

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables K48-linked deubiquitinase activity IDA
IDA: Inferred from direct assay
27013495 MGI
enables K63-linked deubiquitinase activity IDA
IDA: Inferred from direct assay
27013495 MGI
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
27013495 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
27013495 MGI
Biological Process GO Annotation Evidence References Source
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
27013495 MGI
involved in protein K48-linked deubiquitination IDA
IDA: Inferred from direct assay
27013495 MGI
involved in protein K63-linked deubiquitination IDA
IDA: Inferred from direct assay
27013495 MGI
involved in protein deubiquitination IDA
IDA: Inferred from direct assay
27013495 MGI
involved in protein stabilization IDA
IDA: Inferred from direct assay
27013495 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 27

  • X-linked ubiquitin carboxyl-terminal hydrolase 27

  • X-linked ubiquitin thioesterase 27

  • deubiquitinating enzyme 27

  • ubiquitin specific protease 27, X chromosome

  • ubiquitin thioesterase 27

  • ubiquitin thiolesterase 27

  • ubiquitin-specific-processing protease

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15537 USP27X Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Usp27x NCBI NCBI:389856