Usp27x - ubiquitin specific peptidase 27, X chromosome Gene

Mus musculus

Also known as Sfc11; Usp27

Gene ID: 54651 | Gene type: protein coding

About Usp27x

Summary

Enables Lys48-specific Deubiquitinase activity; Lys63-specific Deubiquitinase activity; and thiol-dependent Deubiquitinase. Involved in positive regulation of apoptotic process; protein deubiquitination; and protein stabilization. Predicted to be located in cytoplasm and nucleus. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 105. Orthologous to human USP27X (ubiquitin specific peptidase 27 X-linked). [provided by Alliance of Genome Resources, Apr 2022]

Usp27x Products(1)

mRNA	Protein	Name
NM_019461.4	NP_062334.2	ubiquitin carboxyl-terminal hydrolase 27

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables K48-linked deubiquitinase activity	IDA IDA: Inferred from direct assay	27013495	MGI
enables K63-linked deubiquitinase activity	IDA IDA: Inferred from direct assay	27013495	MGI
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	27013495	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	27013495	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	27013495	MGI
involved in protein K48-linked deubiquitination	IDA IDA: Inferred from direct assay	27013495	MGI
involved in protein K63-linked deubiquitination	IDA IDA: Inferred from direct assay	27013495	MGI
involved in protein deubiquitination	IDA IDA: Inferred from direct assay	27013495	MGI
involved in protein stabilization	IDA IDA: Inferred from direct assay	27013495	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase 27

X-linked ubiquitin carboxyl-terminal hydrolase 27	X-linked ubiquitin thioesterase 27
deubiquitinating enzyme 27	ubiquitin specific protease 27, X chromosome
ubiquitin thioesterase 27	ubiquitin thiolesterase 27
ubiquitin-specific-processing protease

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15537	USP27X Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Usp27x	NCBI	NCBI:389856

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