Atp8b1 - ATPase, class I, type 8B, member 1 Gene

Mus musculus

Also known as Ic; FIC1

Gene ID: 54670 | Gene type: protein coding

About Atp8b1

Summary

Enables aminophospholipid flippase activity and cardiolipin binding activity. Involved in several processes, including lipid transport; nervous system development; and sensory perception of sound. Acts upstream of or within bile acid metabolic process. Located in plasma membrane and stereocilium. Is expressed in adrenal gland; alimentary system; and liver. Used to study intrahepatic cholestasis. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 1; intrahepatic cholestasis; intrahepatic cholestasis of pregnancy 1; and progressive familial intrahepatic cholestasis 1. Orthologous to human ATP8B1 (ATPase phospholipid transporting 8B1). [provided by Alliance of Genome Resources, Apr 2022]

Atp8b1 Products(1)

mRNA	Protein	Name
NM_001001488.3	NP_001001488.2	phospholipid-transporting ATPase IC

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables aminophospholipid flippase activity	IDA IDA: Inferred from direct assay	20510206	MGI
enables cardiolipin binding	IDA IDA: Inferred from direct assay	20852622	MGI
enables lipid transporter activity	IMP IMP: Inferred from mutant phenotype	20852622	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in aminophospholipid transport	IDA IDA: Inferred from direct assay	20510206	MGI
involved in bile acid and bile salt transport	IMP IMP: Inferred from mutant phenotype	19228692	MGI
acts upstream of or within bile acid metabolic process	IMP IMP: Inferred from mutant phenotype	14976163	MGI
involved in inner ear receptor cell development	IMP IMP: Inferred from mutant phenotype	19478059	MGI
involved in organic anion transport	IMP IMP: Inferred from mutant phenotype	19228692	MGI
involved in regulation of plasma membrane organization	IMP IMP: Inferred from mutant phenotype	26416959	MGI
involved in sensory perception of sound	IMP IMP: Inferred from mutant phenotype	19478059	MGI
involved in vestibulocochlear nerve formation	IMP IMP: Inferred from mutant phenotype	19478059	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	20510206	MGI
located in stereocilium	IDA IDA: Inferred from direct assay	19478059	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

phospholipid-transporting ATPase IC

ATPase 8B1, p type	ATPase B1, class I
P4-ATPase flippase complex alpha subunit ATP8B1	aminophospholipid translocase
familial intrahepatic cholestasis type I	probable phospholipid-transporting ATPase IC

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01239	ATP8B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atp8b1	NCBI	NCBI:5205

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