Atp8b1 - ATPase, class I, type 8B, member 1 Gene

Also Known as Ic; FIC1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54670

Summary

Enables aminophospholipid flippase activity and cardiolipin binding activity. Involved in several processes, including lipid transport; nervous system development; and sensory perception of sound. Acts upstream of or within bile acid metabolic process. Located in plasma membrane and stereocilium. Is expressed in adrenal gland; alimentary system; and liver. Used to study intrahepatic cholestasis. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 1; intrahepatic cholestasis; intrahepatic cholestasis of pregnancy 1; and progressive familial intrahepatic cholestasis 1. Orthologous to human ATP8B1 (ATPase phospholipid transporting 8B1). [provided by Alliance of Genome Resources, Apr 2022]

Atp8b1 Products (1)

mRNA Protein Name
NM_001001488.3 NP_001001488.2 phospholipid-transporting ATPase IC

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables aminophospholipid flippase activity IDA
IDA: Inferred from direct assay
20510206 MGI
enables cardiolipin binding IDA
IDA: Inferred from direct assay
20852622 MGI
enables lipid transporter activity IMP
IMP: Inferred from mutant phenotype
20852622 MGI
Biological Process GO Annotation Evidence References Source
involved in aminophospholipid transport IDA
IDA: Inferred from direct assay
20510206 MGI
involved in bile acid and bile salt transport IMP
IMP: Inferred from mutant phenotype
19228692 MGI
acts upstream of or within bile acid metabolic process IMP
IMP: Inferred from mutant phenotype
14976163 MGI
involved in inner ear receptor cell development IMP
IMP: Inferred from mutant phenotype
19478059 MGI
involved in organic anion transport IMP
IMP: Inferred from mutant phenotype
19228692 MGI
involved in regulation of plasma membrane organization IMP
IMP: Inferred from mutant phenotype
26416959 MGI
involved in sensory perception of sound IMP
IMP: Inferred from mutant phenotype
19478059 MGI
involved in vestibulocochlear nerve formation IMP
IMP: Inferred from mutant phenotype
19478059 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
20510206 MGI
located in stereocilium IDA
IDA: Inferred from direct assay
19478059 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phospholipid-transporting ATPase IC

  • ATPase 8B1, p type

  • ATPase B1, class I

  • P4-ATPase flippase complex alpha subunit ATP8B1

  • aminophospholipid translocase

  • familial intrahepatic cholestasis type I

  • probable phospholipid-transporting ATPase IC

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01239 ATP8B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atp8b1 NCBI NCBI:5205