2. Gene
  3. Pdp1 - pyruvate dehydrogenase phosphatase catalytic subunit 1 Gene

Pdp1 - pyruvate dehydrogenase phosphatase catalytic subunit 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Ppm2c

Gene ID: 54705 | Gene type: protein coding

About Pdp1

Summary

Enables calcium ion binding activity; magnesium ion binding activity; and protein serine/threonine Phosphatase activity. Predicted to be involved in peptidyl-threonine dephosphorylation and positive regulation of pyruvate dehydrogenase activity. Located in mitochondrion. Human ortholog(s) of this gene implicated in obesity and pyruvate decarboxylase deficiency. Orthologous to human PDP1 (pyruvate dehydrogenase Phosphatase catalytic subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Pdp1 Products(2)

mRNA Protein Name
NM_001271108.2 NP_001258037.1 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial isoform 1
NM_019372.4 NP_062245.2 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial isoform 2
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calcium ion binding IMP
IMP: Inferred from mutant phenotype
15210124 RGD
enables magnesium ion binding IDA
IDA: Inferred from direct assay
17532339 RGD
enables protein serine/threonine phosphatase activity IMP
IMP: Inferred from mutant phenotype
15210124 RGD
enables protein-containing complex binding IMP
IMP: Inferred from mutant phenotype
15210124 RGD
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrion IDA
IDA: Inferred from direct assay
9651365 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

pyruvate dehydrogenase [acetyl-transferring]-phosphatase 1, mitochondrial

PDP 1

PDPC 1

protein phosphatase 2C, magnesium dependent, catalytic subunit

pyruvate dehydrogenase phosphatase isoenzyme 1

pyruvate dehyrogenase phosphatase catalytic subunit 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10285 PDP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pdp1 NCBI NCBI:54704