SIDT1 - SID1 transmembrane family member 1 Gene

Also Known as SID1; SID-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54847

About SIDT1

Cytogenetic location: 3q13.2 Genomic coordinates (GRCh38): 3:113,532,555-113,637,111 (from NCBI)

This gene has 12 transcripts (splice variants), 138 orthologues and 1 paralogue. Broad expression in lymph node (RPKM 4.1), brain (RPKM 3.6) and 19 other tissues.

Summary

The protein encoded by this gene belongs to SID1 family of transmembrane dsRNA-gated channels. Family members transport dsRNA into cells and are required for systemic RNA interference. [provided by RefSeq, May 2017]

SIDT1 Products (9)

mRNA Protein Name
NM_001308350.2 NP_001295279.1 SID1 transmembrane family member 1 isoform 1 precursor
NM_001322294.2 NP_001309223.1 SID1 transmembrane family member 1 isoform 3 precursor
NM_001322295.2 NP_001309224.1 SID1 transmembrane family member 1 isoform 4 precursor
NM_001322296.2 NP_001309225.1 SID1 transmembrane family member 1 isoform 5 precursor
NM_001322297.2 NP_001309226.1 SID1 transmembrane family member 1 isoform 6
NM_001322298.2 NP_001309227.1 SID1 transmembrane family member 1 isoform 7
NM_001322299.2 NP_001309228.1 SID1 transmembrane family member 1 isoform 8
NM_001322300.2 NP_001309229.1 SID1 transmembrane family member 1 isoform 9
NM_017699.3 NP_060169.2 SID1 transmembrane family member 1 isoform 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables cholesterol binding IDA
IDA: Inferred from direct assay
28785058 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIDT1 Protein Structure

SID-1_RNA_chan

SID-1_RNA_chan: dsRNA-gated channel SID-1 (184 - 827)

  • 0
  • 200
  • 400
  • 600
  • 827 a.a.
Protein Preferred Names Protein Names

SID1 transmembrane family member 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12894 SIDT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SIDT1 VGNC VGNC:65138
Macaca mulatta SIDT1 VGNC VGNC:77312
Canis familiaris SIDT1 VGNC VGNC:46165
Rattus norvegicus SIDT1 RGD RGD:1559616
Mus musculus SIDT1 MGD MGI:2443155
Bos taurus SIDT1 VGNC VGNC:53605