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PGPEP1 - pyroglutamyl-peptidase I Gene

Also Known as PGI; PGP; Pcp; PGPI; PAP-I; PGP-I

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54858

About PGPEP1

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:18,340,598-18,369,950 (from NCBI)

This gene has 9 transcripts (splice variants), 255 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 13.0), duodenum (RPKM 6.7) and 25 other tissues.

Summary

The gene encodes a cysteine protease and member of the peptidase C15 family of proteins. The encoded protein cleaves amino terminal pyroglutamate residues from protein substrates including thyrotropin-releasing hormone and Other neuropeptides. Expression of this gene may be downregulated in colorectal Cancer, while activity of the encoded protein may be negatively correlated with Cancer progression in colorectal Cancer patients. Activity of the encoded protease may also be altered in Other disease states including in liver cirrhosis, which is associated with reduced protease activity, and in necrozoospermia, which is associated with elevated protease activity. [provided by RefSeq, Jul 2016]

PGPEP1 Products (7)

mRNA	Protein	Name
NM_001300927.2	NP_001287856.1	pyroglutamyl-peptidase 1 isoform 2
NM_001308366.2	NP_001295295.1	pyroglutamyl-peptidase 1 isoform 3
NM_001329471.2	NP_001316400.1	pyroglutamyl-peptidase 1 isoform 4
NM_001329476.2	NP_001316405.1	pyroglutamyl-peptidase 1 isoform 6
NM_001329477.2	NP_001316406.1	pyroglutamyl-peptidase 1 isoform 7
NM_001329478.2	NP_001316407.1	pyroglutamyl-peptidase 1 isoform 7
NM_017712.4	NP_060182.1	pyroglutamyl-peptidase 1 isoform 1

PGPEP1 Protein Structure

Peptidase_C15

0
100
209 a.a.

Protein Preferred Names	Protein Names
pyroglutamyl-peptidase 1	5-oxoprolyl-peptidase

Related Diseases

Diseases	Alias
Olecranon Bursitis	Bursitis Of Elbow Bursitis Of Elbow Region Capped Elbow Elbow Bursitis Miner'S Elbow Miners' Elbow Shoe Boil
Cardiomyopathy, Dilated, 1e	Left Ventricular Noncompaction 9 Left Ventricular Noncompaction 5 Dilated Cardiomyopathy 1e Dilated Cardiomyopathy 1s CMD1E Cdcd2 Cardiomyopathy, Dilated, 1y CMD1Y Cardiomyopathy, Dilated, 1s CMD1S Dilated Cardiomyopathy 1y Dilated Cardiomyopathy With Conduction Defect 2 Dilated Cardiomyopathy With Conduction Disorder And Arrhythmia Cardiomyopathy, Dilated, With Conduction Disorder And Arrhythmia Cardiomyopathy, Dilated, With Conduction Defect 2 Cardiomyopathy Dilated With Conduction Defect Type 2 Cardiomyopathy, Dilated 1e Cardiomyopathy, Dilated 1s Cardiomyopathy, Dilated 1y Left Ventricular Non-Compaction 5 LVNC5 Left Ventricular Non-Compaction 9 LVNC9 Cardiomyopathy, Dilated, Type 1e Cardiomyopathy, Dilated, Type 1s Cardiomyopathy, Dilated, Type 1y

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10395	PGPEP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PGPEP1	MGD	MGI:1913772
Bos taurus	PGPEP1	VGNC	VGNC:32799
Canis familiaris	PGPEP1	VGNC	VGNC:44467
Rattus norvegicus	PGPEP1	RGD	RGD:1303133
Felis catus	PGPEP1	VGNC	VGNC:102661
Macaca mulatta	PGPEP1	VGNC	VGNC:75797
Others	PGPEP1	NCBI