SARS2 - seryl-tRNA synthetase 2, mitochondrial Gene

Also Known as SYS; SARS; SERS; SARSM; SerRS; SerRSmt; mtSerRS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54938

About SARS2

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,915,266-38,930,763 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 190 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 6.7), placenta (RPKM 5.6) and 25 other tissues.

Summary

This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]

SARS2 Products (2)

mRNA	Protein	Name
NM_001145901.2	NP_001139373.1	serine--tRNA ligase, mitochondrial isoform a precursor
NM_017827.4	NP_060297.1	serine--tRNA ligase, mitochondrial isoform b precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SARS2 Protein Structure

tRNA-synt_2b

0
100
200
300
400
518 a.a.

Protein Preferred Names	Protein Names
serine--tRNA ligase, mitochondrial	mitochondrial seryl-tRNA synthetase

Related Diseases

Diseases	Alias
Hyperuricemia, Pulmonary Hypertension, Renal Failure, And Alkalosis Syndrome	Hupra Syndrome Alkalosis HUPRAS Hyperuricemia, Pulmonary Hypertension, Renal Failure, And Alkalosis Hyperuricemia, Pulmonary Hypertension, Renal Failure, Alkalosis Syndrome Hyperuricemia-Pulmonary Hypertension-Renal Failure-Alkalosis Syndrome Alkalosis Nos
Hyperuricemia	Blood Urate Raized Uricacidemia
Epithelioid Cell Synovial Sarcoma	Synovial Sarcoma, Epithelioid Cell Epithelioid Synovial Sarcoma
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Hypertension, Pulmonary, Primary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Septal Myocardial Infarction
Capillariasis	Capillaria Infection Enoplida Infections Capillariasis Nos Capillariosis
Acute Stress Disorder	Traumatic Stress Disorder Stress Disorders, Traumatic, Acute Stress Disorders, Traumatic
Venezuelan Hemorrhagic Fever	Guanarito Hemorrhagic Fever Vehf - [Venezuelan Haemorrhagic Fever]
Joubert Syndrome 7	JBTS7 Cerebello-Oculo-Renal Syndrome 3 Cors3 Joubert Syndrome, Type 7
Perrault Syndrome	Gonadal Dysgenesis, Xx Type, With Deafness Ovarian Dysgenesis With Sensorineural Deafness Gonadal Dysgenesis, Xx Type Gonadal Dysgenesis With Auditory Dysfunction, Autosomal Recessive Inheritance Gonadal Dysgenesis With Sensorineural Deafness, Autosomal Recessive Inheritance Xx Gonodal Dysgenesis-Deafness Syndrome Xx Gonodal Dysgenesis-Hearing Loss Syndrome Gonadal Dysgenesis Xx Type Deafness

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-108325	Brequinar	Inhibitor	99.94%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12449	SARS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-108325S	Brequinar-d3	Inhibitor	/	Unkown
HY-180129	SARS-CoV-2-IN-120	Inhibitor	/	Unkown

Bioactive MoleculesInhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990814	Anti-SARS-CoV-2 S protein Antibody (RBD epitope B, SARS2-34)	Inhibitor	/	Unkown
HY-P990815	Anti-SARS-CoV-2 S protein Antibody (RBD epitope A, SARS2-01)	Inhibitor	/	Unkown
HY-P990816	Anti-SARS-CoV-2 S protein Antibody (NTD, SARS2-29)	Inhibitor	/	Unkown
HY-P991763	Anti-SARS-CoV-2 S protein (RBD) Antibody (SARS2-38)	Inhibitor	/	Unkown