OXSM - 3-oxoacyl-ACP synthase, mitochondrial Gene

Also Known as KS; CEM1; KASI; FASN2D

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54995

About OXSM

Cytogenetic location: 3p24.2 Genomic coordinates (GRCh38): 3:25,790,090-25,794,531 (from NCBI)

This gene has 9 transcripts (splice variants), 201 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 3.3), thyroid (RPKM 1.6) and 25 other tissues.

Summary

This gene encodes a beta-ketoacyl synthetase. The encoded enzyme is required for elongation of fatty acid chains in the mitochondria. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009]

OXSM Products (2)

mRNA Protein Name
NM_001145391.2 NP_001138863.1 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform 2 precursor
NM_017897.3 NP_060367.1 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IDA
IDA: Inferred from direct assay
15668256 GOA
Biological Process GO Annotation Evidence References Source
involved in acyl-CoA metabolic process IDA
IDA: Inferred from direct assay
15668256 GOA
involved in medium-chain fatty acid biosynthetic process IDA
IDA: Inferred from direct assay
15668256 GOA
involved in short-chain fatty acid biosynthetic process IDA
IDA: Inferred from direct assay
15668256 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IMP
IMP: Inferred from mutant phenotype
15668256 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OXSM Protein Structure

ketoacyl-synt

ketoacyl-synt: Beta-ketoacyl synthase, N-terminal domain (42 - 290)

Ketoacyl-synt_C

Ketoacyl-synt_C: Beta-ketoacyl synthase, C-terminal domain (299 - 414)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 459 a.a.
Protein Preferred Names Protein Names

3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial

  • 3-ketoacyl-acyl carrier protein synthase

Related Diseases

Diseases Alias
Animal Phobia

  • Zoophobia

  • Fear Of Animals
Gaucher Disease, Type Iii

  • Gaucher Disease, Subacute Neuronopathic Type

  • Gd Iii

  • Gaucher Disease, Chronic Neuronopathic Type

  • Gaucher Disease, Juvenile And Adult, Cerebral

  • Gaucher Disease Type 3

  • GD3

  • Gaucher'S Disease Type Iii

  • Gaucher Disease Type Iii

  • Gd 3

  • Cerebral Juvenile And Adult Form Of Gaucher Disease

  • Chronic Neuronopathic Gaucher Disease

  • Gaucher Disease 3

  • Cerebral, Juvenile And Adult, Gaucher Disease

  • Gaucher Disease Chronic Neuronopathic Type

  • Gaucher Disease Type Ii

  • Subacute Neuronopathic Gaucher Disease

  • Type 3 Gaucher Disease

  • Gaucher Disease, Type 3

  • Gaucher Disease, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09891 OXSM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22266 Oxsm Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28789 Oxsm Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus OXSM VGNC VGNC:32513
Canis familiaris OXSM VGNC VGNC:44204
Felis catus OXSM VGNC VGNC:102794
Rattus norvegicus OXSM RGD RGD:1311092
Mus musculus OXSM MGD MGI:1918397
Macaca mulatta OXSM VGNC VGNC:75681
Others OXSM NCBI