PPP2R3A - protein phosphatase 2 regulatory subunit B''alpha Gene

Homo sapiens

Also known as PR72; PR130; PPP2R3

Gene ID: 5523 | Gene type: protein coding

About PPP2R3A

Cytogenetic location: 3q22.2-q22.3 Genomic coordinates (GRCh38): 3:135,965,728-136,147,894 (from NCBI)

This gene has 5 transcripts (splice variants), 216 orthologues and 1 paralogue. Broad expression in heart (RPKM 10.6), kidney (RPKM 9.3) and 20 other tissues.

Summary

This gene encodes one of the regulatory subunits of the protein Phosphatase 2. Protein Phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein Phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]

PPP2R3A Products(3)

mRNA	Protein	Name
NM_001190447.2	NP_001177376.1	serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 3
NM_002718.5	NP_002709.2	serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 1
NM_181897.3	NP_871626.1	serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 2

PPP2R3A Protein Structure

EF-hand_7

0
200
400
600
800
1000
1150 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

PR130/B''alpha1 subunit

Related Diseases

Diseases

Alias

Ventricular Tachycardia, Catecholaminergic Polymorphic, 2

Catecholaminergic Polymorphic Ventricular Tachycardia 2	CPVT2
Vtsip	Bidirectional Tachycardia
Stress-Induced Polymorphic Ventricular Tachycardia	Ventricular Tachycardia, Stress-Induced Polymorphic
Cvpt2	Double Tachycardia Induced By Catecholamines
Malignant Paroxysmal Ventricular Tachycardia	Multifocal Ventricular Premature Beats
Paroxysmal Ventricular Fibrillation	Syncopal Paroxysmal Tachycardia
Syncopal Tachyarythmia	Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 2
Ventricular Tachycardia, Catecholaminergic Polymorphic, 1	Multifocal Pvcs
Multifocal Premature Ventricular Beats	Paroxysmal Familial Ventricular Fibrillation

Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/Or Dilated Cardiomyopathy

Catecholaminergic Polymorphic Ventricular Tachycardia 1	Ventricular Tachycardia, Catecholaminergic Polymorphic, 1
CPVT1	Ventricular Tachycardia, Stress-Induced Polymorphic
Vtsip	Bidirectional Tachycardia
Stress-Induced Polymorphic Ventricular Tachycardia	Cvpt1
Double Tachycardia Induced By Catecholamines	Malignant Paroxysmal Ventricular Tachycardia
Multifocal Ventricular Premature Beats	Paroxysmal Ventricular Fibrillation
Syncopal Paroxysmal Tachycardia	Syncopal Tachyarythmia
Ventricular Tachycardia Catecholaminergic Polymorphic 1	Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 1
Multifocal Pvcs	Multifocal Premature Ventricular Beats
Paroxysmal Familial Ventricular Fibrillation	Catecholaminergic Polymorphic Ventricular Tachycardia Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11015	PPP2R3A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PPP2R3A	MGD	MGI:2442104
Felis catus	PPP2R3A	VGNC	VGNC:69014
Rattus norvegicus	PPP2R3A	RGD	RGD:1306958
Macaca mulatta	PPP2R3A	VGNC	VGNC:76378
Bos taurus	PPP2R3A	VGNC	VGNC:33258
Canis familiaris	PPP2R3A	VGNC	VGNC:44911
Others	PPP2R3A	NCBI

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