PPP2R3A - protein phosphatase 2 regulatory subunit B''alpha Gene

Also Known as PR72; PR130; PPP2R3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5523

About PPP2R3A

Cytogenetic location: 3q22.2-q22.3 Genomic coordinates (GRCh38): 3:135,965,728-136,147,894 (from NCBI)

This gene has 5 transcripts (splice variants), 216 orthologues and 1 paralogue. Broad expression in heart (RPKM 10.6), kidney (RPKM 9.3) and 20 other tissues.

Summary

This gene encodes one of the regulatory subunits of the protein Phosphatase 2. Protein Phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein Phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]

PPP2R3A Products (3)

mRNA Protein Name
NM_001190447.2 NP_001177376.1 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 3
NM_002718.5 NP_002709.2 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 1
NM_181897.3 NP_871626.1 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9847399 GOA
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
15687260 GOA
Biological Process GO Annotation Evidence References Source
involved in eye photoreceptor cell differentiation IGI
IGI: Inferred from genetic interaction
15687260 GOA
involved in negative regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
15687260 GOA
involved in positive regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
16567647 GOA
involved in positive regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
15687260 GOA
involved in regulation of cell migration involved in somitogenic axis elongation IGI
IGI: Inferred from genetic interaction
15687260 GOA
involved in somatic muscle development IGI
IGI: Inferred from genetic interaction
15687260 GOA
involved in somitogenesis IGI
IGI: Inferred from genetic interaction
15687260 GOA
Cellular Component GO Annotation Evidence References Source
part of protein phosphatase type 2A complex IDA
IDA: Inferred from direct assay
15687260 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP2R3A Protein Structure

EF-hand_7

EF-hand_7: EF-hand domain pair (907 - 1001)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1150 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

  • PR130/B''alpha1 subunit

Related Diseases

Diseases Alias
Ventricular Tachycardia, Catecholaminergic Polymorphic, 2

  • Catecholaminergic Polymorphic Ventricular Tachycardia 2

  • CPVT2

  • Vtsip

  • Bidirectional Tachycardia

  • Stress-Induced Polymorphic Ventricular Tachycardia

  • Ventricular Tachycardia, Stress-Induced Polymorphic

  • Cvpt2

  • Double Tachycardia Induced By Catecholamines

  • Malignant Paroxysmal Ventricular Tachycardia

  • Multifocal Ventricular Premature Beats

  • Paroxysmal Ventricular Fibrillation

  • Syncopal Paroxysmal Tachycardia

  • Syncopal Tachyarythmia

  • Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 2

  • Ventricular Tachycardia, Catecholaminergic Polymorphic, 1

  • Multifocal Pvcs

  • Multifocal Premature Ventricular Beats

  • Paroxysmal Familial Ventricular Fibrillation
Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/Or Dilated Cardiomyopathy

  • Catecholaminergic Polymorphic Ventricular Tachycardia 1

  • Ventricular Tachycardia, Catecholaminergic Polymorphic, 1

  • CPVT1

  • Ventricular Tachycardia, Stress-Induced Polymorphic

  • Vtsip

  • Bidirectional Tachycardia

  • Stress-Induced Polymorphic Ventricular Tachycardia

  • Cvpt1

  • Double Tachycardia Induced By Catecholamines

  • Malignant Paroxysmal Ventricular Tachycardia

  • Multifocal Ventricular Premature Beats

  • Paroxysmal Ventricular Fibrillation

  • Syncopal Paroxysmal Tachycardia

  • Syncopal Tachyarythmia

  • Ventricular Tachycardia Catecholaminergic Polymorphic 1

  • Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 1

  • Multifocal Pvcs

  • Multifocal Premature Ventricular Beats

  • Paroxysmal Familial Ventricular Fibrillation

  • Catecholaminergic Polymorphic Ventricular Tachycardia Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11015 PPP2R3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22019 Ppp2r3a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28537 Ppp2r3a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PPP2R3A MGD MGI:2442104
Felis catus PPP2R3A VGNC VGNC:69014
Rattus norvegicus PPP2R3A RGD RGD:1306958
Macaca mulatta PPP2R3A VGNC VGNC:76378
Bos taurus PPP2R3A VGNC VGNC:33258
Canis familiaris PPP2R3A VGNC VGNC:44911
Others PPP2R3A NCBI