TMEM39A - transmembrane protein 39A Gene

Also Known as SUSR2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55254

About TMEM39A

This gene has 12 transcripts (splice variants), 210 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 7.9), placenta (RPKM 6.8) and 25 other tissues.

Summary

Involved in negative regulation of autophagosome assembly; negative regulation of autophagosome maturation; and positive regulation of viral genome replication. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM39A Products (1)

mRNA	Protein	Name
NM_018266.3	NP_060736.1	transmembrane protein 39A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	31806350	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of autophagosome assembly	IMP IMP: Inferred from mutant phenotype	31806350	GOA
involved in negative regulation of autophagosome maturation	IMP IMP: Inferred from mutant phenotype	31806350	GOA
involved in positive regulation of viral genome replication	IDA IDA: Inferred from direct assay	31849860	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	31806350	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM39A Protein Structure

Tmp39

0
100
200
300
400
488 a.a.

Protein Preferred Names	Protein Names
transmembrane protein 39A	suppressor of SQST-1 aggregates in rpl-43 mutants

Related Diseases

Diseases	Alias
Dowling-Degos Disease	Reticular Pigment Anomaly Of Flexures Dark Dot Disease Reticulate Acropigmentation Of Kitamura Dowling-Degos Kitamura Disease Kitamura Reticulate Acropigmentation Ddd Dowling-Degos-Kitamura Disease Reticular Pigmented Anomaly Of Flexures
Adams-Oliver Syndrome	Adams Oliver Syndrome Aos Congenital Scalp Defects With Distal Limb Reduction Anomalies Aplasia Cutis Congenita With Terminal Transverse Limb Defects Congenital Scalp Defects With Distal Limb Anomalies Limb, Scalp And Skull Defects Limb Scalp And Skull Defects Absence Defect Of Limbs, Scalp, And Skull

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14721	TMEM39A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TMEM39A	VGNC	VGNC:66343
Macaca mulatta	TMEM39A	VGNC	VGNC:79517
Canis familiaris	TMEM39A	VGNC	VGNC:47576
Bos taurus	TMEM39A	VGNC	VGNC:36082
Rattus norvegicus	TMEM39A	RGD	RGD:1306421
Mus musculus	TMEM39A	MGD	MGI:1915096
Others	TMEM39A	NCBI