ELAC1 - elaC ribonuclease Z 1 Gene

Also Known as D29

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55520

About ELAC1

Cytogenetic location: 18q21.2 Genomic coordinates (GRCh38): 18:50,968,040-50,988,121 (from NCBI)

This gene has 4 transcripts (splice variants), 187 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 4.4), testis (RPKM 3.5) and 25 other tissues.

Summary

Predicted to enable 3'-tRNA processing endoribonuclease activity. Predicted to be involved in tRNA 3'-trailer cleavage, endonucleolytic. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ELAC1 Products (1)

mRNA Protein Name
NM_018696.3 NP_061166.1 zinc phosphodiesterase ELAC protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables tRNA-specific ribonuclease activity IDA
IDA: Inferred from direct assay
32075755 GOA
Biological Process GO Annotation Evidence References Source
involved in rescue of stalled ribosome IDA
IDA: Inferred from direct assay
32075755 GOA
involved in tRNA 3'-end processing IDA
IDA: Inferred from direct assay
32075755 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
21593607 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21593607 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELAC1 Protein Structure

Lactamase_B_2

Lactamase_B_2: Beta-lactamase superfamily domain (34 - 314)

  • 0
  • 100
  • 200
  • 300
  • 363 a.a.
Protein Preferred Names Protein Names

zinc phosphodiesterase ELAC protein 1

  • RNase Z 1

Related Diseases

Diseases Alias
Hairy Tongue

  • Overgrowth Of Filiform Papillae

  • Tongue, Hairy
Urethral Diverticulum

  • Urethral Sacculation
Mitochondrial Dna Depletion Syndrome 4b

  • Mitochondrial Neurogastrointestinal Encephalopathy Syndrome

  • Mngie Syndrome

  • Thymidine Phosphorylase Deficiency

  • MTDPS4B

  • Mitochondrial Neurogastrointestinal Encephalopathy Disease

  • Mngie

  • Myoneurogastrointestinal Encephalopathy Syndrome

  • Ogimd

  • Oculogastrointestinal Muscular Dystrophy

  • Polip

  • Polyneuropathy, Ophthalmoplegia, Leukoencephalopathy, And Intestinal Pseudo-Obstruction

  • Mitochondrial Neurogastrointestinal Encephalopathy Syndrome, Polg-Related

  • Mngie, Polg-Related

  • Mepop

  • Mitochondrial Myopathy With Sensorimotor Polyneuropathy, Ophthalmoplegia, And Pseudo-Obstruction

  • Mngie Disease

  • Mitochondrial Dna Depletion Syndrome 4b Mngie Type

  • Mitochondrial Neurogastrointestinal Encephalopathy Syndrome Polg-Related

  • Mngie Polg-Related

  • Mitochondrial Dna Depletion Syndrome, Type 4b

  • Visceral Myopathy Familial External Ophthalmoplegia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04290 ELAC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ELAC1 VGNC VGNC:107703
Canis familiaris ELAC1 VGNC VGNC:56917
Macaca mulatta ELAC1 VGNC VGNC:97764
Rattus norvegicus ELAC1 RGD RGD:1304757
Bos taurus ELAC1 VGNC VGNC:97267
Mus musculus ELAC1 MGD MGI:1890495
Others ELAC1 NCBI