RBM38 - RNA binding motif protein 38 Gene

Also Known as RNPC1; SEB4B; SEB4D; HSRNASEB; dJ800J21.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55544

About RBM38

Cytogenetic location: 20q13.31 Genomic coordinates (GRCh38): 20:57,391,396-57,409,333 (from NCBI)

This gene has 5 transcripts (splice variants), 247 orthologues and 24 paralogues. Broad expression in bone marrow (RPKM 68.1), lymph node (RPKM 23.9) and 18 other tissues.

Summary

Enables mRNA 3'-UTR binding activity. Involved in DNA damage response, signal transduction by p53 class mediator; negative regulation of cell population proliferation; and regulation of RNA metabolic process. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

RBM38 Products (3)

mRNA Protein Name
NM_001291780.2 NP_001278709.1 RNA-binding protein 38 isoform c
NM_017495.6 NP_059965.2 RNA-binding protein 38 isoform a
NM_183425.3 NP_906270.1 RNA-binding protein 38 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mRNA 3'-UTR binding IDA
IDA: Inferred from direct assay
17050675 GOA
enables mRNA binding IDA
IDA: Inferred from direct assay
17050675 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in 3'-UTR-mediated mRNA stabilization IDA
IDA: Inferred from direct assay
17050675 GOA
involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IDA
IDA: Inferred from direct assay
17050675 GOA
involved in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA
IDA: Inferred from direct assay
17050675 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
17050675 GOA
involved in regulation of RNA splicing IDA
IDA: Inferred from direct assay
19285943 GOA
NOT involved in regulation of cell cycle IDA
IDA: Inferred from direct assay
17050675 GOA
involved in regulation of cell cycle IDA
IDA: Inferred from direct assay
17050675 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
17050675 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17050675 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBM38 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (36 - 93)

  • 0
  • 100
  • 200
  • 239 a.a.
Protein Preferred Names Protein Names

RNA-binding protein 38

  • CLL-associated antigen KW-5

Related Diseases

Diseases Alias
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Erythema Infectiosum

  • Fifth Disease

  • Slapped Cheek Syndrome

  • Parvovirus B19 Infection
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11750 RBM38 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RBM38 RGD RGD:1308503
Macaca mulatta RBM38 VGNC VGNC:76484
Mus musculus RBM38 MGD MGI:1889294
Canis familiaris RBM38 VGNC VGNC:54726
Bos taurus RBM38 VGNC VGNC:33798
Others RBM38 NCBI