KIF16B - kinesin family member 16B Gene

Also Known as SNX23; C20orf23; KISC20ORF

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55614

About KIF16B

Cytogenetic location: 20p12.1 Genomic coordinates (GRCh38): 20:16,272,104-16,573,448 (from NCBI)

This gene has 6 transcripts (splice variants), 166 orthologues and 41 paralogues. Ubiquitous expression in adrenal (RPKM 10.5), colon (RPKM 7.0) and 24 other tissues.

Summary

The protein encoded by this gene is a kinesin-like protein that may be involved in intracellular trafficking. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

KIF16B Products (4)

mRNA	Protein	Name
NM_001199865.2	NP_001186794.1	kinesin-like protein KIF16B isoform 3
NM_001199866.2	NP_001186795.1	kinesin-like protein KIF16B isoform 1
NM_001410853.1	NP_001397782.1	kinesin-like protein KIF16B isoform 4
NM_024704.5	NP_078980.3	kinesin-like protein KIF16B isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA IDA: Inferred from direct assay	15882625	GOA
enables phosphatidylinositol-3,4-bisphosphate binding	IDA IDA: Inferred from direct assay	15882625	GOA
enables phosphatidylinositol-3,5-bisphosphate binding	IDA IDA: Inferred from direct assay	17641687	GOA
enables phosphatidylinositol-3-phosphate binding	IDA IDA: Inferred from direct assay	15882625	GOA
enables plus-end-directed microtubule motor activity	IDA IDA: Inferred from direct assay	15882625	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in early endosome to late endosome transport	IMP IMP: Inferred from mutant phenotype	15882625	GOA
involved in epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15882625	GOA
involved in receptor catabolic process	IMP IMP: Inferred from mutant phenotype	15882625	GOA
involved in regulation of receptor recycling	IMP IMP: Inferred from mutant phenotype	15882625	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18445686	GOA
located in early endosome	IDA IDA: Inferred from direct assay	15882625	GOA
located in endosome	IDA IDA: Inferred from direct assay	17641687	GOA
located in spindle	IDA IDA: Inferred from direct assay	18445686	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIF16B Protein Structure

Kinesin

FHA

PX

0
300
600
900
1200
1317 a.a.

Protein Preferred Names	Protein Names
kinesin-like protein KIF16B	kinesin motor protein

Related Diseases

Diseases	Alias
Congenital Fibrosis Of The Extraocular Muscles	Congenital Fibrosis Of Extraocular Muscles Cfeom Feom Congenital External Ophthalmoplegia Congenital Fibrosis Syndrome General Fibrosis Syndrome
Megabladder, Congenital	MGBL Congenital Megabladder
Small Intestine Neuroendocrine Neoplasm	Small Intestine Neuroendocrine Tumor Neuroendocrine Tumor Of The Small Intestine Net Of The Small Intestine Neuroendocrine Neoplasm Of The Small Intestine Neuroendocrine Tumor Of Small Bowel Small Intestinal Neuroendocrine Neoplasm
Combined Oxidative Phosphorylation Deficiency 20	COXPD20 Combined Oxidative Phosphorylation Defect Type 20 Oxidative Phosphorylation Deficiency, Combined, Type 20

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07265	KIF16B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	KIF16B	VGNC	VGNC:63105
Macaca mulatta	KIF16B	VGNC	VGNC:73839
Rattus norvegicus	KIF16B	RGD	RGD:1310146
Mus musculus	KIF16B	MGD	MGI:1098240
Bos taurus	KIF16B	VGNC	VGNC:30585
Canis familiaris	KIF16B	VGNC	VGNC:42385
Others	KIF16B	NCBI