DDX27 - DEAD-box helicase 27 Gene

Also Known as DRS1; RHLP; Drs1p; PP3241; HSPC259; dJ686N3.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55661

About DDX27

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:49,219,416-49,244,073 (from NCBI)

This gene has 5 transcripts (splice variants), 200 orthologues and 38 paralogues. Ubiquitous expression in testis (RPKM 18.7), lymph node (RPKM 16.9) and 25 other tissues.

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. [provided by RefSeq, Jan 2017]

DDX27 Products (2)

mRNA Protein Name
NM_001348187.2 NP_001335116.2 probable ATP-dependent RNA helicase DDX27 isoform 1
NM_017895.8 NP_060365.8 probable ATP-dependent RNA helicase DDX27 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25825154 GOA
Biological Process GO Annotation Evidence References Source
involved in rRNA processing IMP
IMP: Inferred from mutant phenotype
25825154 GOA
Cellular Component GO Annotation Evidence References Source
located in chromosome IDA
IDA: Inferred from direct assay
20813266 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
25825154 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDX27 Protein Structure

DEAD

DEAD: DEAD/DEAH box helicase (242 - 412)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (485 - 558)

  • 0
  • 200
  • 400
  • 600
  • 796 a.a.
Protein Preferred Names Protein Names

probable ATP-dependent RNA helicase DDX27

  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 27

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03641 DDX27 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta DDX27 VGNC VGNC:84726
Mus musculus DDX27 MGD MGI:2385884
Felis catus DDX27 VGNC VGNC:80082
Canis familiaris DDX27 VGNC VGNC:54646
Rattus norvegicus DDX27 RGD RGD:1305634
Bos taurus DDX27 VGNC VGNC:56183
Others DDX27 NCBI