DENND4C - DENN domain containing 4C Gene

Also Known as C9orf55; C9orf55B; RAB10GEF; bA513M16.3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55667

About DENND4C

This gene has 9 transcripts (splice variants), 210 orthologues and 3 paralogues. Ubiquitous expression in duodenum (RPKM 11.5), skin (RPKM 11.0) and 25 other tissues.

Summary

Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in cellular response to Insulin stimulus; protein localization to plasma membrane; and regulation of Rab protein signal transduction. Located in Golgi apparatus and cytosol. [provided by Alliance of Genome Resources, Apr 2022]

DENND4C Products (21)

mRNA	Protein	Name
NM_001330640.2	NP_001317569.1	DENN domain-containing protein 4C isoform 2
NM_001386026.2	NP_001372955.1	DENN domain-containing protein 4C isoform 5
NM_001386030.1	NP_001372959.1	DENN domain-containing protein 4C isoform 6
NM_001386031.1	NP_001372960.1	DENN domain-containing protein 4C isoform 7
NM_001386032.1	NP_001372961.1	DENN domain-containing protein 4C isoform 4
NM_001386034.1	NP_001372963.1	DENN domain-containing protein 4C isoform 4
NM_001386035.1	NP_001372964.1	DENN domain-containing protein 4C isoform 8
NM_001386036.1	NP_001372965.1	DENN domain-containing protein 4C isoform 9
NM_001386037.1	NP_001372966.1	DENN domain-containing protein 4C isoform 10
NM_001386038.1	NP_001372967.1	DENN domain-containing protein 4C isoform 11
NM_001386039.1	NP_001372968.1	DENN domain-containing protein 4C isoform 12
NM_001386040.1	NP_001372969.1	DENN domain-containing protein 4C isoform 13
NM_001386041.1	NP_001372970.1	DENN domain-containing protein 4C isoform 14
NM_001386042.1	NP_001372971.1	DENN domain-containing protein 4C isoform 15
NM_001386043.1	NP_001372972.1	DENN domain-containing protein 4C isoform 3
NM_001386044.1	NP_001372973.1	DENN domain-containing protein 4C isoform 3
NM_001386045.1	NP_001372974.1	DENN domain-containing protein 4C isoform 16
NM_001386046.1	NP_001372975.1	DENN domain-containing protein 4C isoform 17
NM_001386047.1	NP_001372976.1	DENN domain-containing protein 4C isoform 2
NM_001386048.1	NP_001372977.1	DENN domain-containing protein 4C isoform 3
NM_017925.7	NP_060395.5	DENN domain-containing protein 4C isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	20937701	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DENND4C Protein Structure

uDENN

DENN

dDENN

0
300
600
900
1200
1500
1800
1909 a.a.

Protein Preferred Names	Protein Names
DENN domain-containing protein 4C	DENN/MADD domain containing 4A pseudogene

Related Diseases

Diseases	Alias
Alkuraya-Kucinskas Syndrome	ALKKUCS Kiaa1109-Related Early Lethal Congenital Brain Malformations-Arthrogryposis Syndrome Arthrogryposis
Spastic Paraplegia 39, Autosomal Recessive	SPG39 Ntemnd Hereditary Spastic Paraplegia 39 Nte-Related Motor Neuron Disorder Autosomal Recessive Spastic Paraplegia Type 39 Spastic Paraplegia Due To Neuropathy Target Esterase Mutation Spastic Paraplegia Due To Nte Mutation Spastic Paraplegia 39 Autosomal Recessive Spastic Paraplegia 39 Nte Related Motor Neuron Disorder Paraplegia, Spastic, Type 39
Lissencephaly 8	LIS8
Early Infantile Epileptic Encephalopathy	Early Infantile Epileptic Encephalopathy With Burst-Suppression Early Infantile Epileptic Encephalopathy With Suppression Bursts Eiee Early Infantile Epileptic Encephalopathy With Suppression-Bursts Ohtahara Syndrome Encephalopathy, Epileptic, Early Infantile

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03689	DENND4C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DENND4C	VGNC	VGNC:71715
Felis catus	DENND4C	VGNC	VGNC:61438
Rattus norvegicus	DENND4C	RGD	RGD:1308489
Bos taurus	DENND4C	VGNC	VGNC:28001
Mus musculus	DENND4C	MGD	MGI:1914769
Canis familiaris	DENND4C	VGNC	VGNC:39892