DOK4 - docking protein 4 Gene

Also Known as IRS5; IRS-5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55715

About DOK4

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:57,471,922-57,487,322 (from NCBI)

This gene has 18 transcripts (splice variants), 198 orthologues and 7 paralogues. Ubiquitous expression in colon (RPKM 23.2), small intestine (RPKM 21.5) and 25 other tissues.

Summary

Predicted to be involved in positive regulation of MAPK cascade and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within nervous system development. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DOK4 Products (16)

mRNA Protein Name
NM_001330556.2 NP_001317485.1 docking protein 4 isoform 2
NM_001369618.1 NP_001356547.1 docking protein 4 isoform 2
NM_001369619.1 NP_001356548.1 docking protein 4 isoform 1
NM_001369620.1 NP_001356549.1 docking protein 4 isoform 2
NM_001369621.1 NP_001356550.1 docking protein 4 isoform 1
NM_001394652.1 NP_001381581.1 docking protein 4 isoform 2
NM_001394653.1 NP_001381582.1 docking protein 4 isoform 2
NM_001394654.1 NP_001381583.1 docking protein 4 isoform 2
NM_001394655.1 NP_001381584.1 docking protein 4 isoform 2
NM_001394656.1 NP_001381585.1 docking protein 4 isoform 2
NM_001394657.1 NP_001381586.1 docking protein 4 isoform 1
NM_001394658.1 NP_001381587.1 docking protein 4 isoform 1
NM_001394659.1 NP_001381588.1 docking protein 4 isoform 1
NM_001394660.1 NP_001381589.1 docking protein 4 isoform 1
NM_001394661.1 NP_001381590.1 docking protein 4 isoform 1
NM_018110.5 NP_060580.2 docking protein 4 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16273093 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DOK4 Protein Structure

PH

PH: PH domain (8 - 108)

IRS

IRS: PTB domain (IRS-1 type) (137 - 230)

  • 0
  • 100
  • 200
  • 300
  • 326 a.a.
Protein Preferred Names Protein Names

docking protein 4

  • downstream of tyrosine kinase 4

Related Diseases

Diseases Alias
Nephronophthisis 3

  • NPHP3

  • Nph3

  • Adolescent Nephronophthisis

  • Nephronophthisis, Type 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03936 DOK4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris DOK4 VGNC VGNC:40058
Bos taurus DOK4 VGNC VGNC:28168
Mus musculus DOK4 MGD MGI:2148865
Rattus norvegicus DOK4 RGD RGD:1310084
Felis catus DOK4 VGNC VGNC:61583
Macaca mulatta DOK4 VGNC VGNC:71867
Others DOK4 NCBI