DEPDC1B - DEP domain containing 1B Gene

Homo sapiens

Also known as XTP1; BRCC3

Gene ID: 55789 | Gene type: protein coding

About DEPDC1B

Cytogenetic location: 5q12.1 Genomic coordinates (GRCh38): 5:60,596,912-60,700,166 (from NCBI)

This gene has 6 transcripts (splice variants), 201 orthologues and 3 paralogues. Broad expression in gall bladder (RPKM 6.2), testis (RPKM 3.3) and 14 other tissues.

Summary

Predicted to enable GTPase activator activity. Involved in cell migration and positive regulation of Wnt signaling pathway. [provided by Alliance of Genome Resources, Apr 2022]

DEPDC1B Products(2)

mRNA	Protein	Name
NM_001145208.2	NP_001138680.1	DEP domain-containing protein 1B isoform 2
NM_018369.3	NP_060839.2	DEP domain-containing protein 1B isoform 1

DEPDC1B Protein Structure

DEP

RhoGAP

0
100
200
300
400
500
529 a.a.

Protein Preferred Names

Protein Names

DEP domain-containing protein 1B

HBV X-transactivated gene 8 protein

Related Diseases

Diseases

Alias

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03694	DEPDC1B Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DEPDC1B	VGNC	VGNC:71705
Mus musculus	DEPDC1B	MGD	MGI:2145425
Felis catus	DEPDC1B	VGNC	VGNC:61444
Rattus norvegicus	DEPDC1B	RGD	RGD:1305799
Bos taurus	DEPDC1B	VGNC	VGNC:28005
Canis familiaris	DEPDC1B	VGNC	VGNC:39897

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