DEPDC1B - DEP domain containing 1B Gene

Also Known as XTP1; BRCC3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55789

About DEPDC1B

Cytogenetic location: 5q12.1 Genomic coordinates (GRCh38): 5:60,596,912-60,700,166 (from NCBI)

This gene has 6 transcripts (splice variants), 201 orthologues and 3 paralogues. Broad expression in gall bladder (RPKM 6.2), testis (RPKM 3.3) and 14 other tissues.

Summary

Predicted to enable GTPase activator activity. Involved in cell migration and positive regulation of Wnt signaling pathway. [provided by Alliance of Genome Resources, Apr 2022]

DEPDC1B Products (2)

mRNA Protein Name
NM_001145208.2 NP_001138680.1 DEP domain-containing protein 1B isoform 2
NM_018369.3 NP_060839.2 DEP domain-containing protein 1B isoform 1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cell migration IMP
IMP: Inferred from mutant phenotype
24971537 GOA
involved in positive regulation of Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
24971537 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DEPDC1B Protein Structure

DEP

DEP: Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) (28 - 106)

RhoGAP

RhoGAP: RhoGAP domain (270 - 342)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 529 a.a.
Protein Preferred Names Protein Names

DEP domain-containing protein 1B

  • HBV X-transactivated gene 8 protein

Related Diseases

Diseases Alias
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03694 DEPDC1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta DEPDC1B VGNC VGNC:71705
Mus musculus DEPDC1B MGD MGI:2145425
Felis catus DEPDC1B VGNC VGNC:61444
Rattus norvegicus DEPDC1B RGD RGD:1305799
Bos taurus DEPDC1B VGNC VGNC:28005
Canis familiaris DEPDC1B VGNC VGNC:39897
Others DEPDC1B NCBI