METTL2B - methyltransferase 2B, methylcytidine Gene

Also Known as METL; METTL2; METTL2A; PSENIP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55798

About METTL2B

Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:128,476,748-128,506,602 (from NCBI)

This gene has 7 transcripts (splice variants), 200 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 7.8), fat (RPKM 7.8) and 25 other tissues.

Summary

This gene is a member of a family of methyltransferases that share homology with, but are distinct from, the UbiE family of methyltransferases. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

METTL2B Products (1)

mRNA Protein Name
NM_018396.3 NP_060866.2 tRNA N(3)-methylcytidine methyltransferase METTL2B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32427860 GOA
enables tRNA (cytidine) methyltransferase activity IMP
IMP: Inferred from mutant phenotype
21518805 GOA
enables tRNA (cytidine-3-)-methyltransferase activity IMP
IMP: Inferred from mutant phenotype
28655767 GOA
Biological Process GO Annotation Evidence References Source
involved in tRNA metabolic process IMP
IMP: Inferred from mutant phenotype
28655767 GOA
involved in tRNA methylation IMP
IMP: Inferred from mutant phenotype
21518805 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
34268557 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

METTL2B Protein Structure

Methyltransf_23

Methyltransf_23: Methyltransferase domain (181 - 343)

  • 0
  • 100
  • 200
  • 300
  • 378 a.a.
Protein Preferred Names Protein Names

tRNA N(3)-methylcytidine methyltransferase METTL2B

  • methyltransferase like 2B

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08363 METTL2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus METTL2B MGD MGI:1289171