WWC3 - WWC family member 3 Gene

Also Known as BM042

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55841

About WWC3

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:10,015,254-10,144,474 (from NCBI)

This gene has 2 transcripts (splice variants), 192 orthologues and 2 paralogues. Ubiquitous expression in lung (RPKM 15.2), placenta (RPKM 10.3) and 25 other tissues.

Summary

This gene encodes a member of the WWC family of proteins, which also includes the WWC1 (KIBRA) gene product and the WWC2 gene product. The protein encoded by this gene includes a C2 domain, which is known to mediate homodimerization in the related WWC1 gene product. [provided by RefSeq, Sep 2011]

WWC3 Products (1)

mRNA Protein Name
NM_015691.5 NP_056506.3 protein WWC3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables kinase binding IPI
IPI: Inferred from physical interaction
24682284 GOA
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
24682284 GOA
enables signaling adaptor activity IDA
IDA: Inferred from direct assay
35429439 GOA
Biological Process GO Annotation Evidence References Source
involved in hippo signaling IDA
IDA: Inferred from direct assay
35429439 GOA
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
24682284 GOA
involved in negative regulation of hippo signaling IDA
IDA: Inferred from direct assay
24682284 GOA
involved in negative regulation of organ growth IMP
IMP: Inferred from mutant phenotype
24682284 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
24682284 GOA
Cellular Component GO Annotation Evidence References Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
35429439 GOA
located in cytosol IDA
IDA: Inferred from direct assay
24682284 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein WWC3

Related Diseases

Diseases Alias
Nivelon-Nivelon-Mabille Syndrome

  • Chondrodysplasia-Pseudohermaphroditism Syndrome

  • NNMS

  • Chondrodysplasia-Disorder Of Sex Development Syndrome

  • Nivelon Nivelon Mabille Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15858 WWC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28884 Wwc3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris WWC3 VGNC VGNC:48441
Bos taurus WWC3 VGNC VGNC:36976
Felis catus WWC3 VGNC VGNC:67098
Rattus norvegicus WWC3 RGD RGD:1560666
Macaca mulatta WWC3 VGNC VGNC:79790