ZNF395 - zinc finger protein 395 Gene

Also Known as PBF; PRF1; HDBP2; PRF-1; HDBP-2; HDRF-2; Si-1-8-14

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55893

About ZNF395

Cytogenetic location: 8p21.1 Genomic coordinates (GRCh38): 8:28,345,590-28,386,460 (from NCBI)

This gene has 11 transcripts (splice variants), 257 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 29.1), placenta (RPKM 20.8) and 25 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]

ZNF395 Products (1)

mRNA Protein Name
NM_018660.3 NP_061130.1 zinc finger protein 395

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
14625278 GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
28316371 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
14625278 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
14625278 GOA
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11853404 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17531190 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
28316371 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
14625278 GOA
located in nucleus IDA
IDA: Inferred from direct assay
14625278 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

zinc finger protein 395

  • HD gene regulatory region-binding protein 2

Related Diseases

Diseases Alias
Huntington Disease

  • Huntington'S Disease

  • Huntington Chorea

  • Huntington'S Chorea

  • HD

  • Huntington Chronic Progressive Hereditary Chorea

  • Juvenile Huntington Disease

  • Chronic Progressive Chorea

  • Chronic Progressive Hereditary Chorea

  • Hc - [Huntington Chorea]

  • Hereditary Chorea

  • Progressive Hereditary Chorea
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16136 ZNF395 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ZNF395 VGNC VGNC:48717
Bos taurus ZNF395 VGNC VGNC:37266
Macaca mulatta ZNF395 VGNC VGNC:104508
Mus musculus ZNF395 MGD MGI:2682318
Rattus norvegicus ZNF395 RGD RGD:1307849
Felis catus ZNF395 VGNC VGNC:67304
Others ZNF395 NCBI