UNC45A - unc-45 myosin chaperone A Gene

Also Known as OOHE; SMAP1; SMAP-1; GCUNC45; UNC-45A; GC-UNC45; GCUNC-45; IRO039700

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55898

About UNC45A

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:90,930,180-90,954,093 (from NCBI)

This gene has 17 transcripts (splice variants), 199 orthologues, 18 paralogues and is associated with 2 phenotypes. Ubiquitous expression in prostate (RPKM 14.4), skin (RPKM 14.0) and 25 other tissues.

Summary

This gene encodes a regulatory component of the Progesterone Receptor/heat shock protein 90 chaperoning complex, which functions in the assembly and folding of the Progesterone Receptor. The encoded protein is thought to be essential for normal cell proliferation, and for the accumulation of Myosin during development of muscle cells. [provided by RefSeq, Sep 2018]

UNC45A Products (5)

mRNA Protein Name
NM_001039675.2 NP_001034764.1 protein unc-45 homolog A isoform 3
NM_001323619.1 NP_001310548.1 protein unc-45 homolog A isoform 2
NM_001323620.2 NP_001310549.1 protein unc-45 homolog A isoform 4
NM_001323621.2 NP_001310550.1 protein unc-45 homolog A isoform 3
NM_018671.5 NP_061141.2 protein unc-45 homolog A isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25036637 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UNC45A Protein Structure

TPR_11

TPR_11: TPR repeat (22 - 88)

TPR_2

TPR_2: Tetratricopeptide repeat (93 - 125)

UNC45-central

UNC45-central: Myosin-binding striated muscle assembly central (289 - 505)

  • 0
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  • 400
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  • 800
  • 944 a.a.
Protein Preferred Names Protein Names

protein unc-45 homolog A

  • general cell UNC45

UNC45A Antibodies

Cat. No. Product Name Application Reactivity
HY-P810065 UNC45A Antibody (YA9409) WB, ICC/IF, IF-Tissue, IP human, mouse, rat

Related Diseases

Diseases Alias
Osteootohepatoenteric Syndrome

  • OOHE

  • O2he
Congenital Diarrhea
Inflammatory Bowel Disease 27

  • IBD27
Diarrhea

  • Diarrhoea

  • Diarrhea Of Presumed Infectious Origin
Cholestasis

  • Obstruction Of Bile Duct

  • Bile Duct Obstruction

  • Bile Occlusion

  • Extrahepatic Biliary Obstruction

  • Extrahepatic Bile Duct Obstruction

  • Bile Stasis

  • Biliary Stasis

  • Obstructive Hyperbilirubinemia

  • Obstructed Jaundice

  • Bile Duct Obstructed

  • Bile Ductal Obstruction

  • Biliary Duct Obstruction

  • Obstructed Bile Ductal

  • Obstructed Biliary Duct

  • Obstructed Biliary Ductal

  • Jaundice Regurgitation

  • Obstructive Jaundice

  • Cholestatic Jaundice

  • Cholestatic Jaundice Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15468 UNC45A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus UNC45A RGD RGD:1305357
Felis catus UNC45A VGNC VGNC:66825
Bos taurus UNC45A VGNC VGNC:36667
Canis familiaris UNC45A VGNC VGNC:48137
Mus musculus UNC45A MGD MGI:2142246
Macaca mulatta UNC45A VGNC VGNC:79858
Others UNC45A NCBI