AJAP1 - adherens junctions associated protein 1 Gene

Also Known as MOT8; SHREW1; SHREW-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55966

About AJAP1

Cytogenetic location: 1p36.32 Genomic coordinates (GRCh38): 1:4,654,609-4,792,534 (from NCBI)

This gene has 3 transcripts (splice variants) and 195 orthologues. Biased expression in brain (RPKM 4.3), ovary (RPKM 2.3) and 5 other tissues.

Summary

Enables beta-catenin binding activity. Involved in negative regulation of cell-matrix adhesion; negative regulation of wound healing; and regulation of polarized epithelial cell differentiation. Located in several cellular components, including adherens junction; basolateral plasma membrane; and cell-cell contact zone. Is spanning component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

AJAP1 Products (2)

mRNA Protein Name
NM_001042478.2 NP_001035943.1 adherens junction-associated protein 1 precursor
NM_018836.4 NP_061324.1 adherens junction-associated protein 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
14595118 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17267690 GOA
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
14595118 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cell-matrix adhesion IDA
IDA: Inferred from direct assay
16410724 GOA
involved in negative regulation of wound healing IDA
IDA: Inferred from direct assay
16410724 GOA
involved in regulation of polarized epithelial cell differentiation IDA
IDA: Inferred from direct assay
14595118 GOA
Cellular Component GO Annotation Evidence References Source
located in adherens junction IDA
IDA: Inferred from direct assay
14595118 GOA
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
16707570 GOA
located in cell surface IDA
IDA: Inferred from direct assay
14595118 GOA
located in cell-cell contact zone IDA
IDA: Inferred from direct assay
14595118 GOA
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
14595118 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
14595118 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AJAP1 Protein Structure

AJAP1_PANP_C

AJAP1_PANP_C: AJAP1/PANP C-terminus (181 - 388)

  • 0
  • 100
  • 200
  • 300
  • 411 a.a.
Protein Preferred Names Protein Names

adherens junction-associated protein 1

  • membrane protein shrew-1

Related Diseases

Diseases Alias
Dental Caries

  • Dental Caries Extending Into Pulp

  • Dental Caries Of Smooth Surface

  • Dental Caries Pit And Fissure

  • Smooth Surface Dental Caries

  • Dental Decay

  • Carious Teeth

  • Dental Cavity

  • Saprodontia

  • Teeth Decayed

  • Tooth Caries

  • Tooth Decay
Osteogenesis Imperfecta, Type I

  • Osteogenesis Imperfecta Type I

  • OI1

  • Oi, Type I

  • Osteogenesis Imperfecta Tarda

  • Osteogenesis Imperfecta With Blue Sclerae

  • Osteogenesis Imperfecta Type 1

  • Adair-Dighton Syndrome

  • Mild Osteogenesis Imperfecta

  • Non-Deforming Osteogenesis Imperfecta

  • Oi Type 1

  • Van Der Hoeve Syndrome

  • Classic Non-Deforming Oi With Blue Sclerae

  • Osteogenesis Imperfecta 1

  • Oi-I

  • Osteopenic Non-Fracture Syndrome

  • Osteogenesis Imperfecta, Mild

  • Osteogenesis Imperfecta

  • Lobstein'S Disease
Chromosome 1p36 Deletion Syndrome

  • 1p36 Deletion Syndrome

  • Deletion 1p36

  • Monosomy 1p36

  • Subtelomeric 1p36 Deletion

  • Monosomy 1p36 Syndrome

  • Distal Monosomy 1p36

  • Del(1)(P36)

  • Deletion 1pter

  • Monosomy 1pter
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00502 AJAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta AJAP1 VGNC VGNC:106318
Rattus norvegicus AJAP1 RGD RGD:1590138
Bos taurus AJAP1 VGNC VGNC:25768
Canis familiaris AJAP1 VGNC VGNC:37744
Felis catus AJAP1 VGNC VGNC:107485
Mus musculus AJAP1 MGD MGI:2685419
Others AJAP1 NCBI