AJAP1 - adherens junctions associated protein 1 Gene

Homo sapiens

Also known as MOT8; SHREW1; SHREW-1

Gene ID: 55966 | Gene type: protein coding

About AJAP1

Cytogenetic location: 1p36.32 Genomic coordinates (GRCh38): 1:4,654,609-4,792,534 (from NCBI)

This gene has 3 transcripts (splice variants) and 195 orthologues. Biased expression in brain (RPKM 4.3), ovary (RPKM 2.3) and 5 other tissues.

Summary

Enables beta-catenin binding activity. Involved in negative regulation of cell-matrix adhesion; negative regulation of wound healing; and regulation of polarized epithelial cell differentiation. Located in several cellular components, including adherens junction; basolateral plasma membrane; and cell-cell contact zone. Is spanning component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

AJAP1 Products(2)

mRNA	Protein	Name
NM_001042478.2	NP_001035943.1	adherens junction-associated protein 1 precursor
NM_018836.4	NP_061324.1	adherens junction-associated protein 1 precursor

AJAP1 Protein Structure

AJAP1_PANP_C

0
100
200
300
411 a.a.

Protein Preferred Names

Protein Names

adherens junction-associated protein 1

membrane protein shrew-1

Related Diseases

Diseases

Alias

Dental Caries

Dental Caries Extending Into Pulp	Dental Caries Of Smooth Surface
Dental Caries Pit And Fissure	Smooth Surface Dental Caries
Dental Decay	Carious Teeth
Dental Cavity	Saprodontia
Teeth Decayed	Tooth Caries
Tooth Decay

Osteogenesis Imperfecta, Type I

Osteogenesis Imperfecta Type I	OI1
Oi, Type I	Osteogenesis Imperfecta Tarda
Osteogenesis Imperfecta With Blue Sclerae	Osteogenesis Imperfecta Type 1
Adair-Dighton Syndrome	Mild Osteogenesis Imperfecta
Non-Deforming Osteogenesis Imperfecta	Oi Type 1
Van Der Hoeve Syndrome	Classic Non-Deforming Oi With Blue Sclerae
Osteogenesis Imperfecta 1	Oi-I
Osteopenic Non-Fracture Syndrome	Osteogenesis Imperfecta, Mild
Osteogenesis Imperfecta	Lobstein'S Disease

Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome	Deletion 1p36
Monosomy 1p36	Subtelomeric 1p36 Deletion
Monosomy 1p36 Syndrome	Distal Monosomy 1p36
Del(1)(P36)	Deletion 1pter
Monosomy 1pter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00502	AJAP1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	AJAP1	VGNC	VGNC:106318
Rattus norvegicus	AJAP1	RGD	RGD:1590138
Bos taurus	AJAP1	VGNC	VGNC:25768
Canis familiaris	AJAP1	VGNC	VGNC:37744
Felis catus	AJAP1	VGNC	VGNC:107485
Mus musculus	AJAP1	MGD	MGI:2685419

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