Nprl2 - NPR2 like, GATOR1 complex subunit Gene

Also Known as G21; NPR2L; Tusc4; 2810446G01Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56032

Summary

Predicted to enable protein kinase activity. Predicted to contribute to GTPase activator activity. Predicted to be involved in several processes, including cellular response to starvation; negative regulation of TOR signaling; and regulation of autophagosome assembly. Predicted to be located in lysosomal membrane. Predicted to be part of GATOR1 complex. Human ortholog(s) of this gene implicated in focal epilepsy. Orthologous to human NPRL2 (NPR2 like, GATOR1 complex subunit). [provided by Alliance of Genome Resources, Apr 2022]

Nprl2 Products (1)

mRNA Protein Name
NM_018879.2 NP_061367.1 GATOR complex protein NPRL2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cellular response to amino acid starvation IMP
IMP: Inferred from mutant phenotype
29768191 MGI
involved in negative regulation of TORC1 signaling IMP
IMP: Inferred from mutant phenotype
26166573 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

GATOR complex protein NPRL2

  • NPR2-like protein

  • gene 21 protein

  • nitrogen permase homolog

  • nitrogen permease regulator 2-like protein

  • nitrogen permease regulator-like 2

  • tumor suppressor candidate 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09500 NPRL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nprl2 NCBI NCBI:10641