TEX15 - testis expressed 15, meiosis and synapsis associated Gene

Also Known as CT42; SPGF25

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 56154

About TEX15

Cytogenetic location: 8p12 Genomic coordinates (GRCh38): 8:30,831,544-30,913,008 (from NCBI)

This gene has 4 transcripts (splice variants), 124 orthologues and is associated with 2 phenotypes. Biased expression in testis (RPKM 7.9) and endometrium (RPKM 3.5).

Summary

This gene encodes a protein that is required for DNA double-strand break repair, chromosome synapsis, and meiotic recombination in spermatocytes. Male mice with a knockout of the orthologous gene are viable but sterile. Loss-of-function mutations in the orthologous mouse gene cause early meiotic arrest in spermatocytes, before the mid-pachytene stage. Naturally occurring mutations in this gene are associated with nonobstructive azoospermia. [provided by RefSeq, Apr 2017]

TEX15 Products (1)

mRNA	Protein	Name
NM_001350162.2	NP_001337091.1	testis-expressed protein 15

TEX15 Protein Structure

TEX15

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2789 a.a.

Protein Preferred Names	Protein Names
testis-expressed protein 15	cancer/testis antigen 42

Related Diseases

Diseases	Alias
Spermatogenic Failure 25	SPGF25
Spermatogenic Failure 1	Oligosynaptic Infertility SPGF1 Oligochiasmatic Infertility Oligochiasmic Infertility
Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism
Infertility
Spermatogenic Failure 10	SPGF10 Spermatogenic Failure With Defective Sperm Annulus
Spermatogenic Failure 9	Male Infertility Due To Globozoospermia SPGF9 Male Infertility Due To Round-Headed Spermatozoa Globozoospermia, Complete Globozoospermia, Total Globozoospermia Globozoospermia Syndrome Round-Headed Sperm Syndrome Globozoospermia Complete Globozoospermia Total
Spermatogenic Failure, X-Linked, 1	Sertoli Cell-Only Syndrome Germinal Cell Aplasia Del Castillo Syndrome SPGFX1 X-Linked Spermatogenic Failure 1 Congenital Absence Of Germinal Epithelium Of Testes
Spermatogenic Failure 5	Male Infertility With Large-Headed, Multiflagellar, Polyploid Spermatozoa Infertility Associated With Multi-Tailed Spermatozoa And Excessive Dna SPGF5 Macrocephalic Sperm Head Syndrome Male Infertility Due To Macrozoospermia Infertility Associated With Multitailed Spermatozoa And Excessive Dna Macrozoospermia Male Infertility Due To Large-Headed Multiflagellar Polyploid Spermatozoa Infertility Associated With Multi-Tailed Spermatozoa And Excessive Deoxyribonucleic Acid Large-Headed Multiflagellar Polyploid Spermatozoa Male Infertility With Large-Headed Multiflagellar Polyploid Spermatozoa
Vas Deferens, Congenital Bilateral Aplasia Of	Congenital Bilateral Absence Of Vas Deferens CBAVD Cavd Congenital Bilateral Aplasia Of Vas Deferens Congenital Bilateral Absence Of The Vas Deferens Congenital Bilateral Agenesis Of Vas Deferens Absence Of Vas Deferens Absent Vasa Congenital Absence Of Vas Deferens Congenital Aplasia Of Vas Deferens Absent Vas Deferens Vas Deferens, Congenital Bilateral Absence

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14392	TEX15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TEX15	VGNC	VGNC:78318
Bos taurus	TEX15	VGNC	VGNC:58420
Felis catus	TEX15	VGNC	VGNC:107473
Rattus norvegicus	TEX15	RGD	RGD:1311266
Canis familiaris	TEX15	VGNC	VGNC:47268
Mus musculus	TEX15	MGD	MGI:1934816
Others	TEX15	NCBI