TDRD1 - tudor domain containing 1 Gene

Also Known as CT41.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56165

About TDRD1

Cytogenetic location: 10q25.3 Genomic coordinates (GRCh38): 10:114,174,874-114,232,666 (from NCBI)

This gene has 4 transcripts (splice variants), 198 orthologues and 6 paralogues. Biased expression in testis (RPKM 8.5) and prostate (RPKM 0.6).

Summary

This gene encodes a protein containing a tudor domain that is thought to function in the suppression of transposable elements during spermatogenesis. The related protein in mouse forms a complex with piRNAs and Piwi proteins to promote methylation and silencing of target sequences. This gene was observed to be upregulated by ETS transcription factor ERG in prostate tumors. [provided by RefSeq, Sep 2018]

TDRD1 Products (13)

mRNA Protein Name
NM_001365891.2 NP_001352820.1 tudor domain-containing protein 1 isoform 2
NM_001385363.1 NP_001372292.1 tudor domain-containing protein 1 isoform 1
NM_001385364.2 NP_001372293.1 tudor domain-containing protein 1 isoform 3
NM_001385365.1 NP_001372294.1 tudor domain-containing protein 1 isoform 4
NM_001385366.1 NP_001372295.1 tudor domain-containing protein 1 isoform 5
NM_001385367.1 NP_001372296.1 tudor domain-containing protein 1 isoform 6
NM_001385368.1 NP_001372297.1 tudor domain-containing protein 1 isoform 7
NM_001385369.1 NP_001372298.1 tudor domain-containing protein 1 isoform 7
NM_001385370.1 NP_001372299.1 tudor domain-containing protein 1 isoform 8
NM_001385371.1 NP_001372300.1 tudor domain-containing protein 1 isoform 9
NM_001385372.1 NP_001372301.1 tudor domain-containing protein 1 isoform 10
NM_001395205.1 NP_001382134.1 tudor domain-containing protein 1 isoform 3
NM_198795.2 NP_942090.1 tudor domain-containing protein 1 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TDRD1 Protein Structure

zf-MYND

zf-MYND: MYND finger (170 - 206)

TUDOR

TUDOR: Tudor domain (261 - 382)

TUDOR

TUDOR: Tudor domain (492 - 611)

TUDOR

TUDOR: Tudor domain (712 - 831)

TUDOR

TUDOR: Tudor domain (937 - 1059)

  • 0
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  • 1189 a.a.
Protein Preferred Names Protein Names

tudor domain-containing protein 1

  • cancer/testis antigen 41.1

Related Diseases

Diseases Alias
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14334 TDRD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TDRD1 MGD MGI:1933218
Canis familiaris TDRD1 VGNC VGNC:47220
Felis catus TDRD1 VGNC VGNC:66046
Macaca mulatta TDRD1 VGNC VGNC:78299
Rattus norvegicus TDRD1 RGD RGD:1306140
Bos taurus TDRD1 VGNC VGNC:35715
Others TDRD1 NCBI