2. Gene
  3. Fxyd1 - FXYD domain-containing ion transport regulator 1 Gene

Fxyd1 - FXYD domain-containing ion transport regulator 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Plm; Pml; 0610012C17Rik; 1110006M24Rik

Gene ID: 56188 | Gene type: protein coding

About Fxyd1

Summary

This gene encodes a member of the FXYD family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved Amino acids. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity and act as an accessory protein of Na,K-ATPase. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]

Fxyd1 Products(4)

mRNA Protein Name
NM_019503.4 NP_062376.2 phospholemman isoform a precursor
NM_052991.4 NP_443717.1 phospholemman isoform b precursor
NM_052992.3 NP_443718.1 phospholemman isoform b precursor
NM_194321.2 NP_919302.1 phospholemman isoform b precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables sodium channel regulator activity IMP
IMP: Inferred from mutant phenotype
15563542 MGI
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of sodium ion export across plasma membrane IMP
IMP: Inferred from mutant phenotype
17095720 MGI
involved in regulation of cardiac muscle cell membrane potential IMP
IMP: Inferred from mutant phenotype
17095720 MGI
involved in regulation of sodium ion transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
15563542 MGI
Cellular Component GO Annotation Evidence Reference Source
located in sarcolemma IMP
IMP: Inferred from mutant phenotype
15563542 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phospholemman

sodium/potassium-transporting ATPase subunit FXYD1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05165 FXYD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fxyd1 NCBI NCBI:5348