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Stx1b - syntaxin 1B Gene

Also Known as Stx1b; Syn1b; Stx1b2; Stx1bl

Species: Mus musculus

Gene Type: protein coding

Gene ID: 56216

Summary

Enables protein kinase binding activity and signaling receptor binding activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of synaptic vesicle recycling; and neurotransmitter secretion. Located in axon; plasma membrane; and presynapse. Is active in neuromuscular junction. Is expressed in forebrain and retina layer. Human ortholog(s) of this gene implicated in generalized epilepsy with febrile seizures plus 9. Orthologous to human STX1B (syntaxin 1B). [provided by Alliance of Genome Resources, Apr 2022]

Stx1b Products (1)

mRNA	Protein	Name
NM_024414.2	NP_077725.1	syntaxin-1B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15774481	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	21307259	MGI
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	21424589	MGI

Biological Process GO Annotation	Evidence	Verweise	Source
involved in calcium ion-regulated exocytosis of neurotransmitter	IMP IMP: Inferred from mutant phenotype	18703708	MGI
involved in negative regulation of synaptic vesicle recycling	IMP IMP: Inferred from mutant phenotype	24587181	MGI
involved in positive regulation of excitatory postsynaptic potential	IGI IGI: Inferred from genetic interaction	24133272	MGI
involved in positive regulation of neurotransmitter secretion	IGI IGI: Inferred from genetic interaction	24133272	MGI
involved in positive regulation of spontaneous neurotransmitter secretion	IMP IMP: Inferred from mutant phenotype	24587181	MGI
involved in regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24133272	MGI
involved in regulation of synaptic vesicle priming	IGI IGI: Inferred from genetic interaction	24133272	MGI
involved in spontaneous neurotransmitter secretion	IGI IGI: Inferred from genetic interaction	24133272	MGI
involved in spontaneous neurotransmitter secretion	IMP IMP: Inferred from mutant phenotype	18703708	MGI
involved in synaptic vesicle docking	IGI IGI: Inferred from genetic interaction	24133272	MGI
involved in synaptic vesicle docking	IMP IMP: Inferred from mutant phenotype	24587181	MGI
involved in synaptic vesicle exocytosis	IDA IDA: Inferred from direct assay	27466336	MGI
involved in synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	27466336	MGI
involved in synaptic vesicle fusion to presynaptic active zone membrane	IDA IDA: Inferred from direct assay	24587181	MGI
involved in synaptic vesicle fusion to presynaptic active zone membrane	IEP IEP: Inferred from expression pattern	24587181	MGI
involved in synaptic vesicle fusion to presynaptic active zone membrane	IMP IMP: Inferred from mutant phenotype	24587181	MGI
involved in vesicle docking involved in exocytosis	IMP IMP: Inferred from mutant phenotype	18703708	MGI

Cellular Component GO Annotation	Evidence	Verweise	Source
located in axon	IDA IDA: Inferred from direct assay	23821748	MGI
located in membrane	IDA IDA: Inferred from direct assay	10468580	MGI
is active in neuromuscular junction	IDA IDA: Inferred from direct assay	24587181	MGI
is active in neuromuscular junction	IEP IEP: Inferred from expression pattern	24587181	MGI
is active in neuromuscular junction	IMP IMP: Inferred from mutant phenotype	24587181	MGI
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	24133272	MGI
located in presynapse	IMP IMP: Inferred from mutant phenotype	18703708	MGI
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	23821748	MGI
is active in presynaptic active zone membrane	IMP IMP: Inferred from mutant phenotype	23821748	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
syntaxin-1B	syntaxin 1B1 syntaxin 1B2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS13981	STX1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stx1b	NCBI	NCBI:112755