Espn - espin Gene

Also Known as je

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56226

Summary

Predicted to enable SH3 domain binding activity and actin filament binding activity. Involved in negative regulation of Cytoskeleton organization. Acts upstream of or within locomotory behavior; parallel actin filament bundle assembly; and positive regulation of filopodium assembly. Located in actin cytoskeleton; brush border; and stereocilium. Is active in stereocilium tip. Is expressed in organ of Corti; seminiferous tubule; and seminiferous tubule epithelium. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 36. Orthologous to human ESPN (espin). [provided by Alliance of Genome Resources, Apr 2022]

Espn Products (6)

mRNA Protein Name
NM_019585.3 NP_062531.2 espin isoform 6
NM_207687.3 NP_997570.1 espin isoform 1
NM_207688.2 NP_997571.1 espin isoform 2
NM_207689.2 NP_997572.1 espin isoform 4
NM_207690.2 NP_997573.1 espin isoform 5
NM_207691.2 NP_997574.2 espin isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22264607 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin filament bundle assembly IDA
IDA: Inferred from direct assay
10588661 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
16962269 MGI
involved in negative regulation of cytoskeleton organization IDA
IDA: Inferred from direct assay
15190118 MGI
acts upstream of or within parallel actin filament bundle assembly IDA
IDA: Inferred from direct assay
10588661 MGI
acts upstream of or within positive regulation of filopodium assembly IGI
IGI: Inferred from genetic interaction
22264607 MGI
acts upstream of or within positive regulation of filopodium assembly IPI
IPI: Inferred from physical interaction
22264607 MGI
Cellular Component GO Annotation Evidence References Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
10588661 MGI
located in brush border IDA
IDA: Inferred from direct assay
22114352 MGI
located in stereocilium IDA
IDA: Inferred from direct assay
20510926 MGI
located in stereocilium bundle IDA
IDA: Inferred from direct assay
20016102 MGI
is active in stereocilium tip EXP
EXP: Inferred from Experiment
26754646 MGI
located in stereocilium tip IDA
IDA: Inferred from direct assay
22264607 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

espin

  • actin cytoskeletal regulatory protein

  • ectoplasmic specialization protein

  • jerker

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04528 ESPN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Espn NCBI NCBI:83715