2. Gene
  3. Espn - espin Gene

Espn - espin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as je

Gene ID: 56226 | Gene type: protein coding

About Espn

Summary

Predicted to enable SH3 domain binding activity and actin filament binding activity. Involved in negative regulation of Cytoskeleton organization. Acts upstream of or within locomotory behavior; parallel actin filament bundle assembly; and positive regulation of filopodium assembly. Located in actin cytoskeleton; brush border; and stereocilium. Is active in stereocilium tip. Is expressed in organ of Corti; seminiferous tubule; and seminiferous tubule epithelium. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 36. Orthologous to human ESPN (espin). [provided by Alliance of Genome Resources, Apr 2022]

Espn Products(6)

mRNA Protein Name
NM_019585.3 NP_062531.2 espin isoform 6
NM_207687.3 NP_997570.1 espin isoform 1
NM_207688.2 NP_997571.1 espin isoform 2
NM_207689.2 NP_997572.1 espin isoform 4
NM_207690.2 NP_997573.1 espin isoform 5
NM_207691.2 NP_997574.2 espin isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
22264607 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within actin filament bundle assembly IDA
IDA: Inferred from direct assay
10588661 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
16962269 MGI
involved in negative regulation of cytoskeleton organization IDA
IDA: Inferred from direct assay
15190118 MGI
acts upstream of or within parallel actin filament bundle assembly IDA
IDA: Inferred from direct assay
10588661 MGI
acts upstream of or within positive regulation of filopodium assembly IGI
IGI: Inferred from genetic interaction
22264607 MGI
acts upstream of or within positive regulation of filopodium assembly IPI
IPI: Inferred from physical interaction
22264607 MGI
Cellular Component GO Annotation Evidence Reference Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
10588661 MGI
located in brush border IDA
IDA: Inferred from direct assay
22114352 MGI
located in stereocilium IDA
IDA: Inferred from direct assay
20510926 MGI
located in stereocilium bundle IDA
IDA: Inferred from direct assay
20016102 MGI
is active in stereocilium tip EXP
EXP: Inferred from Experiment
26754646 MGI
located in stereocilium tip IDA
IDA: Inferred from direct assay
22264607 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

espin

actin cytoskeletal regulatory protein

ectoplasmic specialization protein

jerker

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04528 ESPN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Espn NCBI NCBI:83715