Espn - espin Gene

Also Known as Je

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 56227

Summary

Enables SH3 domain binding activity and actin filament binding activity. Predicted to be involved in microvillar actin bundle assembly and negative regulation of Cytoskeleton organization. Predicted to act upstream of or within locomotory behavior; parallel actin filament bundle assembly; and positive regulation of filopodium assembly. Located in several cellular components, including actin cytoskeleton; brush border; and microvillus. Part of filamentous actin. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 36. Orthologous to human ESPN (espin). [provided by Alliance of Genome Resources, Apr 2022]

Espn Products (1)

mRNA Protein Name
NM_019622.2 NP_062568.2 espin

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SH3 domain binding IPI
IPI: Inferred from physical interaction
12598619 RGD
enables actin filament binding IDA
IDA: Inferred from direct assay
8799813 RGD
Cellular Component GO Annotation Evidence References Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
16413524 RGD
located in brush border IDA
IDA: Inferred from direct assay
9763424 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
16413524 RGD
part of filamentous actin IDA
IDA: Inferred from direct assay
8799813 RGD
located in microvillus IDA
IDA: Inferred from direct assay
16413524 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

espin

  • Jerker, deafness locus

  • actin cytoskeletal regulatory protein

  • ectoplasmic specialization protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04528 ESPN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Espn NCBI NCBI:83715