2. Gene
  3. Espn - espin Gene

Espn - espin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Je

Gene ID: 56227 | Gene type: protein coding

About Espn

Summary

Enables SH3 domain binding activity and actin filament binding activity. Predicted to be involved in microvillar actin bundle assembly and negative regulation of Cytoskeleton organization. Predicted to act upstream of or within locomotory behavior; parallel actin filament bundle assembly; and positive regulation of filopodium assembly. Located in several cellular components, including actin cytoskeleton; brush border; and microvillus. Part of filamentous actin. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 36. Orthologous to human ESPN (espin). [provided by Alliance of Genome Resources, Apr 2022]

Espn Products(1)

mRNA Protein Name
NM_019622.2 NP_062568.2 espin
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables SH3 domain binding IPI
IPI: Inferred from physical interaction
12598619 RGD
enables actin filament binding IDA
IDA: Inferred from direct assay
8799813 RGD
Cellular Component GO Annotation Evidence Reference Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
16413524 RGD
located in brush border IDA
IDA: Inferred from direct assay
9763424 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
16413524 RGD
part of filamentous actin IDA
IDA: Inferred from direct assay
8799813 RGD
located in microvillus IDA
IDA: Inferred from direct assay
16413524 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

espin

Jerker, deafness locus

actin cytoskeletal regulatory protein

ectoplasmic specialization protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04528 ESPN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Espn NCBI NCBI:83715