BEX4 - brain expressed X-linked 4 Gene

Also Known as BEXL1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56271

About BEX4

Cytogenetic location: Xq22.1 Genomic coordinates (GRCh38): X:103,215,092-103,217,246 (from NCBI)

This gene has 2 transcripts (splice variants) and 80 orthologues. Ubiquitous expression in brain (RPKM 111.7), thyroid (RPKM 67.9) and 23 other tissues.

Summary

This gene is a member of the brain expressed X-linked gene family. The proteins encoded by some of the Other members of this family act as transcription elongation factors which allow RNA polymerase II to escape pausing during elongation. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2011]

BEX4 Products (2)

mRNA Protein Name
NM_001080425.4 NP_001073894.1 protein BEX4
NM_001127688.2 NP_001121160.1 protein BEX4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables alpha-tubulin binding IDA
IDA: Inferred from direct assay
27512957 GOA
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
27512957 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Referencias Source
involved in chromosome segregation IMP
IMP: Inferred from mutant phenotype
27512957 GOA
involved in negative regulation of tubulin deacetylation IMP
IMP: Inferred from mutant phenotype
27512957 GOA
involved in regulation of cell migration IMP
IMP: Inferred from mutant phenotype
27512957 GOA
involved in regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
27512957 GOA
Cellular Component GO Annotation Evidence Referencias Source
located in cytoplasm IDA
IDA: Inferred from direct assay
27512957 GOA
located in microtubule IDA
IDA: Inferred from direct assay
27512957 GOA
located in nucleus IDA
IDA: Inferred from direct assay
27512957 GOA
located in spindle pole IDA
IDA: Inferred from direct assay
27512957 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BEX4 Protein Structure

BEX

BEX: Brain expressed X-linked like family (15 - 119)

  • 0
  • 100
  • 120 a.a.
Protein Preferred Names Protein Names

protein BEX4

  • BEX family member 4

Related Diseases

Diseases Alias
Hypoglycemia, Leucine-Induced

  • Leucine-Sensitive Hypoglycemia Of Infancy

  • Leucine-Induced Hypoglycemia

  • LIH

  • Hypoglycemia Of Infancy, Leucine-Sensitive

  • Familial Infantile Hypoglycemia Precipitated By Leucine

  • Hypoglycemia Leucine Induced

  • Hypoglycemia Leucine-Induced
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS01483 BEX4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus BEX4 MGD MGI:3606746
Rattus norvegicus BEX4 RGD RGD:1564749
Others BEX4 NCBI