Amotl2 - angiomotin-like 2 Gene

Mus musculus

Also known as Lccp; MASCOT; mKIAA0989

Gene ID: 56332 | Gene type: protein coding

About Amotl2

Summary

Enables identical protein binding activity. Predicted to be involved in several processes, including angiogenesis; establishment of cell polarity involved in ameboidal cell migration; and hippo signaling. Predicted to act upstream of or within Wnt signaling pathway. Located in apical plasma membrane; bicellular tight junction; and cytoplasmic vesicle. Is expressed in several structures, including axial skeleton; brain ventricular layer; dorsal aorta; and telencephalon. Orthologous to human AMOTL2 (angiomotin like 2). [provided by Alliance of Genome Resources, Apr 2022]

Amotl2 Products(1)

mRNA	Protein	Name
NM_019764.2	NP_062738.2	angiomotin-like protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin filament binding	IMP IMP: Inferred from mutant phenotype	24806444	MGI
enables identical protein binding	IDA IDA: Inferred from direct assay	16019084	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16019084	MGI
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	24806444	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in endothelial cell morphogenesis	IMP IMP: Inferred from mutant phenotype	24806444	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	17397395	MGI
located in bicellular tight junction	IDA IDA: Inferred from direct assay	16019084	MGI
located in cell junction	IDA IDA: Inferred from direct assay	24806444	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	24806444	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	17397395	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

angiomotin-like protein 2

Leman coiled-coil protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00665	AMOTL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Amotl2	NCBI	NCBI:51421

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