Amotl2 - angiomotin-like 2 Gene

Also Known as Lccp; MASCOT; mKIAA0989

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56332

Summary

Enables identical protein binding activity. Predicted to be involved in several processes, including angiogenesis; establishment of cell polarity involved in ameboidal cell migration; and hippo signaling. Predicted to act upstream of or within Wnt signaling pathway. Located in apical plasma membrane; bicellular tight junction; and cytoplasmic vesicle. Is expressed in several structures, including axial skeleton; brain ventricular layer; dorsal aorta; and telencephalon. Orthologous to human AMOTL2 (angiomotin like 2). [provided by Alliance of Genome Resources, Apr 2022]

Amotl2 Products (1)

mRNA Protein Name
NM_019764.2 NP_062738.2 angiomotin-like protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin filament binding IMP
IMP: Inferred from mutant phenotype
24806444 MGI
enables identical protein binding IDA
IDA: Inferred from direct assay
16019084 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16019084 MGI
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
24806444 MGI
Biological Process GO Annotation Evidence References Source
involved in endothelial cell morphogenesis IMP
IMP: Inferred from mutant phenotype
24806444 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
17397395 MGI
located in bicellular tight junction IDA
IDA: Inferred from direct assay
16019084 MGI
located in cell junction IDA
IDA: Inferred from direct assay
24806444 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
24806444 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
17397395 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

angiomotin-like protein 2

  • Leman coiled-coil protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00665 AMOTL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Amotl2 NCBI NCBI:51421