Kcnj1 - potassium inwardly-rectifying channel, subfamily J, member 1 Gene

Also Known as ROMK; Romk2; Kir1.1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56379

Summary

Predicted to enable several functions, including ATP-activated inward rectifier Potassium Channel activity; anion binding activity; and potassium ion binding activity. Acts upstream of or within several processes, including regulation of G-protein activated inward rectifier Potassium Channel activity; renal sodium ion absorption; and tissue homeostasis. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in heart and metanephros. Used to study Bartter disease type 2. Human ortholog(s) of this gene implicated in Bartter disease type 2. Orthologous to human KCNJ1 (potassium inwardly rectifying channel subfamily J member 1). [provided by Alliance of Genome Resources, Apr 2022]

Kcnj1 Products (2)

mRNA Protein Name
NM_001168354.1 NP_001161826.1 ATP-sensitive inward rectifier potassium channel 1 isoform 1
NM_019659.3 NP_062633.1 ATP-sensitive inward rectifier potassium channel 1 isoform 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within circulatory system development IMP
IMP: Inferred from mutant phenotype
12122007 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
21081491 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
12122007 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
12122007 MGI
acts upstream of or within regulation of G-protein activated inward rectifier potassium channel activity IMP
IMP: Inferred from mutant phenotype
12130653 MGI
acts upstream of or within renal sodium ion absorption IMP
IMP: Inferred from mutant phenotype
12122007 MGI
acts upstream of or within tissue homeostasis IMP
IMP: Inferred from mutant phenotype
12122007 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-sensitive inward rectifier potassium channel 1

  • ATP-regulated potassium channel ROM-K

  • inward rectifier K(+) channel Kir1.1

  • inwardly rectifying potassium channel ROMK-2

  • potassium channel, inwardly rectifying subfamily J member 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P5887 Tertiapin-RQ Inhibitor / Unkown
HY-RS07136 KCNJ1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22587 Kcnj3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnj1 NCBI NCBI:3758