Mbtps1 - membrane-bound transcription factor peptidase, site 1 Gene

Also Known as S1P; Ski1; SKI-1; mKIAA0091; 0610038M03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56453

Summary

Enables serine-type endopeptidase activity. Acts upstream of or within lipid metabolic process and protein import into nucleus. Located in Golgi stack. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in spondyloepiphyseal dysplasia Kondo-Fu type. Orthologous to human MBTPS1 (membrane bound transcription factor peptidase, site 1). [provided by Alliance of Genome Resources, Apr 2022]

Mbtps1 Products (2)

mRNA Protein Name
NM_001167910.1 NP_001161382.1 membrane-bound transcription factor site-1 protease precursor
NM_019709.4 NP_062683.3 membrane-bound transcription factor site-1 protease precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables serine-type endopeptidase activity IDA
IDA: Inferred from direct assay
9990022 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within lipid metabolic process IMP
IMP: Inferred from mutant phenotype
11717426 MGI
involved in membrane protein intracellular domain proteolysis IDA
IDA: Inferred from direct assay
16417584 MGI
involved in mitotic G2 DNA damage checkpoint signaling IDA
IDA: Inferred from direct assay
37178686 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi stack IDA
IDA: Inferred from direct assay
9990022 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

membrane-bound transcription factor site-1 protease

  • S1P endopeptidase

  • endopeptidase S1P

  • membrane-bound transcription factor protease, site 1

  • site-1 protease

  • sterol-regulated luminal protease

  • subtilisin/kexin isozyme 1

  • subtilisin/kexin isozyme SKI-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08198 MBTPS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20177 Mbtps1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26681 Mbtps1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mbtps1 NCBI NCBI:8720