Zbtb20 - zinc finger and BTB domain containing 20 Gene

Also Known as HOF; J20; DPZF; Oda8; ODA-8S; Zfp288; D16Wsu73e; 1300017A20Rik; 7330412A13Rik; A930017C21Rik; Tg(PDGFB-APPSwInd)20Lms

Species: Mus musculus

Gene Type: protein coding

Gene ID: 56490

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to glucose stimulus; positive regulation of glycolytic process; and regulation of gene expression. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human ZBTB20 (zinc finger and BTB domain containing 20). [provided by Alliance of Genome Resources, Apr 2022]

Zbtb20 Products (6)

mRNA	Protein	Name
NM_001285805.1	NP_001272734.1	zinc finger and BTB domain-containing protein 20 isoform L
NM_001393397.1	NP_001380326.1	zinc finger and BTB domain-containing protein 20 isoform L
NM_001393398.1	NP_001380327.1	zinc finger and BTB domain-containing protein 20 isoform L
NM_001393399.1	NP_001380328.1	zinc finger and BTB domain-containing protein 20 isoform S
NM_019778.2	NP_062752.2	zinc finger and BTB domain-containing protein 20 isoform L
NM_181058.1	NP_851401.1	zinc finger and BTB domain-containing protein 20 isoform S

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	11744704	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	18669658	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	28327662	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	28327662	MGI
involved in lipid homeostasis	IMP IMP: Inferred from mutant phenotype	28327662	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	23776228	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23776228	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18669658	MGI
involved in positive regulation of glycolytic process	IMP IMP: Inferred from mutant phenotype	28327662	MGI
involved in positive regulation of interferon-beta production	IDA IDA: Inferred from direct assay	23776228	MGI
involved in positive regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	23776228	MGI
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	23776228	MGI
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	23776228	MGI
involved in positive regulation of lipid biosynthetic process	IMP IMP: Inferred from mutant phenotype	28327662	MGI
involved in positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	23776228	MGI
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	23776228	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	28327662	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11744704	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
zinc finger and BTB domain-containing protein 20	APP Tg BTB/POZ domain zinc finger factor HOF PDGF-APPSwInd PDGF-hAPP695,751,770V171F, KM670/671NL POZ/zinc finger transcription factor ODA-8 zinc finger protein 288

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15968	ZBTB20 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Zbtb20	NCBI	NCBI:26137