Rabgef1 - RAB guanine nucleotide exchange factor (GEF) 1 Gene

Mus musculus

Also known as Rin2; Rab5ef; Rabex5

Gene ID: 56715 | Gene type: protein coding

About Rabgef1

Summary

Enables ubiquitin protein Ligase activity. Acts upstream of or within several processes, including negative regulation of macromolecule metabolic process; regulation of signal transduction; and regulation of vesicle-mediated transport. Located in vesicle. Is expressed in genitourinary system; hippocampus; and retina nuclear layer. Orthologous to human RABGEF1 (RAB guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Rabgef1 Products(8)

mRNA	Protein	Name
NM_001199059.2	NP_001185988.1	rab5 GDP/GTP exchange factor isoform a
NM_001359233.2	NP_001346162.1	rab5 GDP/GTP exchange factor isoform b
NM_001378873.1	NP_001365802.1	rab5 GDP/GTP exchange factor isoform c
NM_001403280.1	NP_001390209.1	rab5 GDP/GTP exchange factor isoform a
NM_001403281.1	NP_001390210.1	rab5 GDP/GTP exchange factor isoform b
NM_001403282.1	NP_001390211.1	rab5 GDP/GTP exchange factor isoform c
NM_001403283.1	NP_001390212.1	rab5 GDP/GTP exchange factor isoform c
NM_019983.3	NP_064367.1	rab5 GDP/GTP exchange factor isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10926822	MGI
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	17341663	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of Kit signaling pathway	IMP IMP: Inferred from mutant phenotype	16533754	MGI
acts upstream of Ras protein signal transduction	IMP IMP: Inferred from mutant phenotype	15235600	MGI
involved in dendritic transport	IDA IDA: Inferred from direct assay	23430262	MGI
involved in dendritic transport	IMP IMP: Inferred from mutant phenotype	23430262	MGI
acts upstream of establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	16533754	MGI
acts upstream of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	16533754	MGI
acts upstream of mast cell cytokine production	IMP IMP: Inferred from mutant phenotype	16533754	MGI
acts upstream of mast cell degranulation	IMP IMP: Inferred from mutant phenotype	15235600	MGI
acts upstream of mast cell migration	IMP IMP: Inferred from mutant phenotype	16533754	MGI
acts upstream of or within negative regulation of Kit signaling pathway	IMP IMP: Inferred from mutant phenotype	16533754	MGI
acts upstream of or within negative regulation of Ras protein signal transduction	IMP IMP: Inferred from mutant phenotype	15235600	MGI
acts upstream of or within negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	15235600	MGI
acts upstream of or within negative regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	16533754	MGI
acts upstream of or within negative regulation of leukocyte migration	IMP IMP: Inferred from mutant phenotype	16533754	MGI
acts upstream of or within negative regulation of mast cell activation	IMP IMP: Inferred from mutant phenotype	15235600	MGI
acts upstream of or within negative regulation of mast cell cytokine production	IMP IMP: Inferred from mutant phenotype	16533754	MGI
acts upstream of or within negative regulation of mast cell degranulation	IMP IMP: Inferred from mutant phenotype	15235600	MGI
acts upstream of or within negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	16533754	MGI
acts upstream of or within negative regulation of receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	16533754	MGI
acts upstream of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	16533754	MGI
acts upstream of receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	16533754	MGI
acts upstream of or within regulation of Fc receptor mediated stimulatory signaling pathway	IDA IDA: Inferred from direct assay	17341663	MGI
acts upstream of or within regulation of Fc receptor mediated stimulatory signaling pathway	IMP IMP: Inferred from mutant phenotype	15235600	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in vesicle	IDA IDA: Inferred from direct assay	17341663	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

rab5 GDP/GTP exchange factor

Rab5 exchange factor	Ras negative regulator Rabex-5
Ras negative regulator Rabex-5/Rin2	rabex-5

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11586	RABGEF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rabgef1	NCBI	NCBI:27342

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