Rabgef1 - RAB guanine nucleotide exchange factor (GEF) 1 Gene

Also Known as Rin2; Rab5ef; Rabex5

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56715

Summary

Enables ubiquitin protein Ligase activity. Acts upstream of or within several processes, including negative regulation of macromolecule metabolic process; regulation of signal transduction; and regulation of vesicle-mediated transport. Located in vesicle. Is expressed in genitourinary system; hippocampus; and retina nuclear layer. Orthologous to human RABGEF1 (RAB guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Rabgef1 Products (8)

mRNA Protein Name
NM_001199059.2 NP_001185988.1 rab5 GDP/GTP exchange factor isoform a
NM_001359233.2 NP_001346162.1 rab5 GDP/GTP exchange factor isoform b
NM_001378873.1 NP_001365802.1 rab5 GDP/GTP exchange factor isoform c
NM_001403280.1 NP_001390209.1 rab5 GDP/GTP exchange factor isoform a
NM_001403281.1 NP_001390210.1 rab5 GDP/GTP exchange factor isoform b
NM_001403282.1 NP_001390211.1 rab5 GDP/GTP exchange factor isoform c
NM_001403283.1 NP_001390212.1 rab5 GDP/GTP exchange factor isoform c
NM_019983.3 NP_064367.1 rab5 GDP/GTP exchange factor isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10926822 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
17341663 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of Kit signaling pathway IMP
IMP: Inferred from mutant phenotype
16533754 MGI
acts upstream of Ras protein signal transduction IMP
IMP: Inferred from mutant phenotype
15235600 MGI
involved in dendritic transport IDA
IDA: Inferred from direct assay
23430262 MGI
involved in dendritic transport IMP
IMP: Inferred from mutant phenotype
23430262 MGI
acts upstream of establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
16533754 MGI
acts upstream of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
16533754 MGI
acts upstream of mast cell cytokine production IMP
IMP: Inferred from mutant phenotype
16533754 MGI
acts upstream of mast cell degranulation IMP
IMP: Inferred from mutant phenotype
15235600 MGI
acts upstream of mast cell migration IMP
IMP: Inferred from mutant phenotype
16533754 MGI
acts upstream of or within negative regulation of Kit signaling pathway IMP
IMP: Inferred from mutant phenotype
16533754 MGI
acts upstream of or within negative regulation of Ras protein signal transduction IMP
IMP: Inferred from mutant phenotype
15235600 MGI
acts upstream of or within negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
15235600 MGI
acts upstream of or within negative regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
16533754 MGI
acts upstream of or within negative regulation of leukocyte migration IMP
IMP: Inferred from mutant phenotype
16533754 MGI
acts upstream of or within negative regulation of mast cell activation IMP
IMP: Inferred from mutant phenotype
15235600 MGI
acts upstream of or within negative regulation of mast cell cytokine production IMP
IMP: Inferred from mutant phenotype
16533754 MGI
acts upstream of or within negative regulation of mast cell degranulation IMP
IMP: Inferred from mutant phenotype
15235600 MGI
acts upstream of or within negative regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
16533754 MGI
acts upstream of or within negative regulation of receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
16533754 MGI
acts upstream of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
16533754 MGI
acts upstream of receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
16533754 MGI
acts upstream of or within regulation of Fc receptor mediated stimulatory signaling pathway IDA
IDA: Inferred from direct assay
17341663 MGI
acts upstream of or within regulation of Fc receptor mediated stimulatory signaling pathway IMP
IMP: Inferred from mutant phenotype
15235600 MGI
Cellular Component GO Annotation Evidence References Source
located in vesicle IDA
IDA: Inferred from direct assay
17341663 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rab5 GDP/GTP exchange factor

  • Rab5 exchange factor

  • Ras negative regulator Rabex-5

  • Ras negative regulator Rabex-5/Rin2

  • rabex-5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11586 RABGEF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rabgef1 NCBI NCBI:27342