PCLO - Pclo piccolo (presynaptic cytomatrix protein) Gene

Also Known as aczonin

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 56768

Summary

Enables calcium ion binding activity; calcium-dependent phospholipid binding activity; and transcription corepressor binding activity. Involved in several processes, including positive regulation of synaptic vesicle recycling; presynaptic active zone assembly; and regulation of endosome size. Located in several cellular components, including cytoplasmic vesicle; distal axon; and rod spherule. Is active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and presynaptic active zone cytoplasmic component. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 3. Orthologous to human PCLO (piccolo presynaptic cytomatrix protein). [provided by Alliance of Genome Resources, Apr 2022]

PCLO Products (2)

mRNA Protein Name
NM_001110797.2 NP_001104267.2 protein piccolo isoform 2
NM_020098.2 NP_064483.2 protein piccolo isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
11285225 RGD
enables calcium-dependent phospholipid binding IDA
IDA: Inferred from direct assay
11285225 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12473661 RGD
enables transcription corepressor binding IPI
IPI: Inferred from physical interaction
25652077 RGD
Biological Process GO Annotation Evidence References Source
involved in modulation of excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
31074746 RGD
involved in positive regulation of synaptic vesicle recycling IMP
IMP: Inferred from mutant phenotype
31074746 RGD
involved in presynaptic active zone assembly IDA
IDA: Inferred from direct assay
22875941 RGD
involved in regulation of endosome size IMP
IMP: Inferred from mutant phenotype
31074746 RGD
involved in regulation of ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
23403927 RGD
involved in synapse organization IDA
IDA: Inferred from direct assay
23403927 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi-associated vesicle IDA
IDA: Inferred from direct assay
22875941 RGD
located in axon IDA
IDA: Inferred from direct assay
11182086 RGD
located in cone cell pedicle IDA
IDA: Inferred from direct assay
11596050 RGD
located in cytoskeleton of presynaptic active zone IDA
IDA: Inferred from direct assay
11596050 RGD
located in dendrite IDA
IDA: Inferred from direct assay
11182086 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
21712437 RGD
located in growth cone IDA
IDA: Inferred from direct assay
11182086 RGD
located in inhibitory synapse IDA
IDA: Inferred from direct assay
11596050 RGD
located in neuromuscular junction IDA
IDA: Inferred from direct assay
17156365 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
11182086 RGD
is active in parallel fiber to Purkinje cell synapse IDA
IDA: Inferred from direct assay
21712437 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
17156365 RGD
located in presynaptic active zone IDA
IDA: Inferred from direct assay
11182086 RGD
is active in presynaptic active zone cytoplasmic component IDA
IDA: Inferred from direct assay
21712437 RGD
located in ribbon synapse IDA
IDA: Inferred from direct assay
21712437 RGD
located in rod spherule IDA
IDA: Inferred from direct assay
11596050 RGD
located in synapse IDA
IDA: Inferred from direct assay
10707984 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
11182086 RGD
located in trans-Golgi network IDA
IDA: Inferred from direct assay
16373352 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein piccolo

  • multidomain presynaptic cytomatrix protein Piccolo

  • presynaptic cytomatrix protein

  • protein piccolo-like

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10155 PCLO Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22272 Pclo Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28795 Pclo Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens PCLO NCBI NCBI:27445