Scube2 - signal peptide, CUB domain, EGF-like 2 Gene

Also Known as Cegf1; Cegp1; 4932442O19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56788

Summary

Enables Hedgehog family protein binding activity. Acts upstream of or within several processes, including positive regulation of chondrocyte proliferation; positive regulation of osteoblast differentiation; and positive regulation of smoothened signaling pathway. Located in extracellular space. Is expressed in several structures, including cardiovascular system; central nervous system; neural ectoderm; skeleton; and tongue. Orthologous to human SCUBE2 (signal peptide, CUB domain and EGF like domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Scube2 Products (2)

mRNA Protein Name
NM_020052.2 NP_064436.2 signal peptide, CUB and EGF-like domain-containing protein 2 precursor
NM_020052.2 NP_064436.2 signal peptide, CUB and EGF-like domain-containing protein 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables hedgehog family protein binding IPI
IPI: Inferred from physical interaction
25639508 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
25639508 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within chondrocyte differentiation involved in endochondral bone morphogenesis IMP
IMP: Inferred from mutant phenotype
25639508 MGI
acts upstream of or within positive regulation of chondrocyte proliferation IMP
IMP: Inferred from mutant phenotype
25639508 MGI
acts upstream of or within positive regulation of ossification IMP
IMP: Inferred from mutant phenotype
25639508 MGI
acts upstream of or within positive regulation of osteoblast differentiation IDA
IDA: Inferred from direct assay
25639508 MGI
acts upstream of or within positive regulation of osteoblast differentiation IGI
IGI: Inferred from genetic interaction
25639508 MGI
acts upstream of or within positive regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
25639508 MGI
acts upstream of or within positive regulation of smoothened signaling pathway IDA
IDA: Inferred from direct assay
25639508 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
25639508 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

signal peptide, CUB and EGF-like domain-containing protein 2

  • CUB domain and EGF-like repeat containing 1

  • scube/You

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12572 SCUBE2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scube2 NCBI NCBI:57758