2. Gene
  3. Scube2 - signal peptide, CUB domain, EGF-like 2 Gene

Scube2 - signal peptide, CUB domain, EGF-like 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Cegf1; Cegp1; 4932442O19Rik

Gene ID: 56788 | Gene type: protein coding

About Scube2

Summary

Enables Hedgehog family protein binding activity. Acts upstream of or within several processes, including positive regulation of chondrocyte proliferation; positive regulation of osteoblast differentiation; and positive regulation of smoothened signaling pathway. Located in extracellular space. Is expressed in several structures, including cardiovascular system; central nervous system; neural ectoderm; skeleton; and tongue. Orthologous to human SCUBE2 (signal peptide, CUB domain and EGF like domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Scube2 Products(2)

mRNA Protein Name
NM_020052.2 NP_064436.2 signal peptide, CUB and EGF-like domain-containing protein 2 precursor
NM_020052.2 NP_064436.2 signal peptide, CUB and EGF-like domain-containing protein 2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables hedgehog family protein binding IPI
IPI: Inferred from physical interaction
25639508 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
25639508 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within chondrocyte differentiation involved in endochondral bone morphogenesis IMP
IMP: Inferred from mutant phenotype
25639508 MGI
acts upstream of or within positive regulation of chondrocyte proliferation IMP
IMP: Inferred from mutant phenotype
25639508 MGI
acts upstream of or within positive regulation of ossification IMP
IMP: Inferred from mutant phenotype
25639508 MGI
acts upstream of or within positive regulation of osteoblast differentiation IDA
IDA: Inferred from direct assay
25639508 MGI
acts upstream of or within positive regulation of osteoblast differentiation IGI
IGI: Inferred from genetic interaction
25639508 MGI
acts upstream of or within positive regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
25639508 MGI
acts upstream of or within positive regulation of smoothened signaling pathway IDA
IDA: Inferred from direct assay
25639508 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
25639508 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

signal peptide, CUB and EGF-like domain-containing protein 2

CUB domain and EGF-like repeat containing 1

scube/You

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12572 SCUBE2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scube2 NCBI NCBI:57758