Cacna2d2 - calcium channel, voltage-dependent, alpha 2/delta subunit 2 Gene

Also Known as du; td; a2d2; torpid; Cacna2d; mKIAA0558

Species: Mus musculus

Gene Type: protein coding

Gene ID: 56808

Summary

Enables voltage-gated Calcium Channel activity. Acts upstream of or within several processes, including neuromuscular junction development; positive regulation of organ growth; and rhythmic synaptic transmission. Part of voltage-gated Calcium Channel complex. Is expressed in several structures, including central nervous system; genitourinary system; heart; lip; and retina. Used to study epilepsy and idiopathic generalized epilepsy. Orthologous to human CACNA2D2 (calcium voltage-gated channel auxiliary subunit alpha2delta 2). [provided by Alliance of Genome Resources, Apr 2022]

Cacna2d2 Products (5)

mRNA	Protein	Name
NM_001174047.1	NP_001167518.1	voltage-dependent calcium channel subunit alpha-2/delta-2 isoform 1 precursor
NM_001174048.1	NP_001167519.1	voltage-dependent calcium channel subunit alpha-2/delta-2 isoform 3 precursor
NM_001174049.1	NP_001167520.1	voltage-dependent calcium channel subunit alpha-2/delta-2 isoform 4 precursor
NM_001174050.1	NP_001167521.1	voltage-dependent calcium channel subunit alpha-2/delta-2 isoform 5 precursor
NM_020263.3	NP_064659.2	voltage-dependent calcium channel subunit alpha-2/delta-2 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables voltage-gated calcium channel activity	IDA IDA: Inferred from direct assay	11487633	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within muscle cell development	IMP IMP: Inferred from mutant phenotype	17320843	MGI
acts upstream of or within neuromuscular junction development	IMP IMP: Inferred from mutant phenotype	17320843	MGI
acts upstream of organ growth	IMP IMP: Inferred from mutant phenotype	9349522	MGI
acts upstream of or within positive regulation of organ growth	IMP IMP: Inferred from mutant phenotype	9349522	MGI
acts upstream of or within regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	17320843	MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	30683685	MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IMP IMP: Inferred from mutant phenotype	30683685	MGI
acts upstream of or within rhythmic synaptic transmission	IMP IMP: Inferred from mutant phenotype	16474392	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	30683685	MGI
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	30683685	MGI
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	30683685	MGI
is active in presynaptic active zone membrane	IMP IMP: Inferred from mutant phenotype	30683685	MGI
part of voltage-gated calcium channel complex	IDA IDA: Inferred from direct assay	11487633	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
voltage-dependent calcium channel subunit alpha-2/delta-2	alpha 2 delta calcium channel subunit ducky protein ducky voltage-dependent calcium channel alpha2/delta-2 voltage-gated calcium channel subunit alpha-2/delta-2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01802	CACNA2D2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cacna2d2	NCBI	NCBI:9254