GPR137 - G protein-coupled receptor 137 Gene

Also Known as C11orf4; GPR137A; TM7SF1L1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56834

About GPR137

This gene has 19 transcripts (splice variants), 175 orthologues and 2 paralogues. Broad expression in testis (RPKM 30.3), brain (RPKM 9.0) and 24 other tissues.

Summary

Predicted to be involved in several processes, including negative regulation of bone resorption; negative regulation of osteoclast differentiation; and positive regulation of TORC1 signaling. Located in lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPR137 Products (18)

mRNA Protein Name
NM_001170880.2 NP_001164351.1 integral membrane protein GPR137 isoform 2
NM_001170881.2 NP_001164352.1 integral membrane protein GPR137 isoform 1
NM_001177358.2 NP_001170829.1 integral membrane protein GPR137 isoform 5
NM_001378076.1 NP_001365005.1 integral membrane protein GPR137 isoform 1
NM_001378077.1 NP_001365006.1 integral membrane protein GPR137 isoform 1
NM_001378078.1 NP_001365007.1 integral membrane protein GPR137 isoform 2
NM_001378079.1 NP_001365008.1 integral membrane protein GPR137 isoform 2
NM_001378080.1 NP_001365009.1 integral membrane protein GPR137 isoform 2
NM_001378081.1 NP_001365010.1 integral membrane protein GPR137 isoform 2
NM_001378082.1 NP_001365011.1 integral membrane protein GPR137 isoform 2
NM_001378083.1 NP_001365012.1 integral membrane protein GPR137 isoform 3
NM_001378084.1 NP_001365013.1 integral membrane protein GPR137 isoform 5
NM_001378085.1 NP_001365014.1 integral membrane protein GPR137 isoform 5
NM_001378086.1 NP_001365015.1 integral membrane protein GPR137 isoform 5
NM_001378087.1 NP_001365016.1 integral membrane protein GPR137 isoform 6
NM_001378088.1 NP_001365017.1 integral membrane protein GPR137 isoform 6
NM_001378089.1 NP_001365018.1 integral membrane protein GPR137 isoform 7
NM_020155.4 NP_064540.3 integral membrane protein GPR137 isoform 3

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in lysosomal membrane IDA
IDA: Inferred from direct assay
31036939 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integral membrane protein GPR137

  • transmembrane 7 superfamily member 1-like 1 protein

Related Diseases

Diseases Alias
Retinitis Pigmentosa 60

  • RP60

  • Retinitis Pigmentosa, Type 60
Isolated Growth Hormone Deficiency, Type Ib

  • Isolated Growth Hormone Deficiency Type Ib

  • IGHD1B

  • Ighd Ib

  • Growth Hormone Deficiency, Isolated, Type Ib

  • Congenital Ighd Type Ib

  • Congenital Isolated Gh Deficiency Type Ib

  • Congenital Isolated Growth Hormone Deficiency Type Ib

  • Dwarfism Of Sindh

  • Pituitary Dwarfism I

  • Isolated Growth Hormone Deficiency Type 1b

  • Ighd 1b

  • Growth Hormone Deficiency, Isolated, 1b
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05658 GPR137 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05659 GPR137B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GPR137 MGD MGI:2147529
Macaca mulatta GPR137 VGNC VGNC:72994
Bos taurus GPR137 VGNC VGNC:29550
Canis familiaris GPR137 VGNC VGNC:41397
Rattus norvegicus GPR137 RGD RGD:1586317
Others GPR137 NCBI