CASS4 - Cas scaffold protein family member 4 Gene

Also Known as CAS4; HEFL; HEPL; C20orf32

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57091

About CASS4

Cytogenetic location: 20q13.31 Genomic coordinates (GRCh38): 20:56,412,036-56,460,382 (from NCBI)

This gene has 5 transcripts (splice variants), 191 orthologues and 3 paralogues. Broad expression in lung (RPKM 5.8), appendix (RPKM 4.9) and 15 other tissues.

Summary

Enables protein tyrosine kinase binding activity. Involved in several processes, including positive regulation of protein kinase B signaling; positive regulation of protein tyrosine kinase activity; and positive regulation of substrate adhesion-dependent cell spreading. Located in focal adhesion. Part of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CASS4 Products (4)

mRNA Protein Name
NM_001164114.2 NP_001157586.1 cas scaffolding protein family member 4 isoform b
NM_001164115.2 NP_001157587.1 cas scaffolding protein family member 4 isoform c
NM_001164116.2 NP_001157588.1 cas scaffolding protein family member 4 isoform a
NM_020356.4 NP_065089.2 cas scaffolding protein family member 4 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
enables protein tyrosine kinase binding IPI
IPI: Inferred from physical interaction
18256281 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
18256281 GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
27677288 GOA
involved in positive regulation of protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
18256281 GOA
involved in positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
18256281 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
23001926 GOA
located in cytoplasm IMP
IMP: Inferred from mutant phenotype
27677288 GOA
located in focal adhesion IDA
IDA: Inferred from direct assay
18256281 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CASS4 Protein Structure

SH3_9

SH3_9: Variant SH3 domain (18 - 66)

Serine_rich

Serine_rich: Serine rich protein interaction domain (435 - 593)

DUF3513

DUF3513: Domain of unknown function (DUF3513) (597 - 785)

  • 0
  • 200
  • 400
  • 600
  • 786 a.a.
Protein Preferred Names Protein Names

cas scaffolding protein family member 4

  • HEF-like protein

Related Diseases

Diseases Alias
Astigmatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01977 CASS4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20870 Cass4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27387 Cass4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CASS4 VGNC VGNC:38741
Rattus norvegicus CASS4 RGD RGD:1310643
Bos taurus CASS4 VGNC VGNC:26789
Mus musculus CASS4 MGD MGI:2444482
Felis catus CASS4 VGNC VGNC:60389
Macaca mulatta CASS4 VGNC VGNC:70562
Others CASS4 NCBI