MAN1C1 - mannosidase alpha class 1C member 1 Gene

Also Known as HMIC; MAN1C; MAN1A3; pp6318

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57134

About MAN1C1

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:25,616,791-25,784,450 (from NCBI)

This gene has 8 transcripts (splice variants), 217 orthologues and 6 paralogues. Ubiquitous expression in kidney (RPKM 10.6), thyroid (RPKM 9.8) and 23 other tissues.

Summary

Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in N-glycan processing. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

MAN1C1 Products (6)

mRNA Protein Name
NM_001289010.2 NP_001275939.1 mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform 2
NM_001385182.1 NP_001372111.1 mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform 3
NM_001385183.1 NP_001372112.1 mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform 4
NM_001385184.1 NP_001372113.1 mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform 5
NM_001385185.1 NP_001372114.1 mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform 6
NM_020379.4 NP_065112.1 mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAN1C1 Protein Structure

Glyco_hydro_47

Glyco_hydro_47: Glycosyl hydrolase family 47 (181 - 617)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 630 a.a.
Protein Preferred Names Protein Names

mannosyl-oligosaccharide 1,2-alpha-mannosidase IC

  • 1,2-alpha-mannosidase IC

Related Diseases

Diseases Alias
Alcohol-Induced Mental Disorder

  • Psychoses, Alcoholic
Substance-Induced Psychosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08007 MAN1C1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MAN1C1 VGNC VGNC:42944
Macaca mulatta MAN1C1 VGNC VGNC:74313
Rattus norvegicus MAN1C1 RGD RGD:1309672
Bos taurus MAN1C1 VGNC VGNC:31163
Mus musculus MAN1C1 MGD MGI:2446214
Felis catus MAN1C1 VGNC VGNC:63374
Others MAN1C1 NCBI