RNPEPL1 - arginyl aminopeptidase like 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57140

About RNPEPL1

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:240,568,484-240,581,372 (from NCBI)

This gene has 10 transcripts (splice variants), 198 orthologues and 11 paralogues. Ubiquitous expression in spleen (RPKM 21.6), fat (RPKM 21.2) and 25 other tissues.

Summary

Enables metalloaminopeptidase activity. Involved in proteolysis. [provided by Alliance of Genome Resources, Apr 2022]

RNPEPL1 Products (1)

mRNA Protein Name
NM_018226.6 NP_060696.4 aminopeptidase RNPEPL1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables metalloaminopeptidase activity IDA
IDA: Inferred from direct assay
11017071 GOA
Biological Process GO Annotation Evidence References Source
involved in proteolysis IDA
IDA: Inferred from direct assay
11017071 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNPEPL1 Protein Structure

Peptidase_M1

Peptidase_M1: Peptidase family M1 domain (7 - 214)

Leuk-A4-hydro_C

Leuk-A4-hydro_C: Leukotriene A4 hydrolase, C-terminal (297 - 442)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 494 a.a.
Protein Preferred Names Protein Names

aminopeptidase RNPEPL1

  • RNPEP-like 1

Related Diseases

Diseases Alias
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12107 RNPEPL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22024 Rnpepl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28542 Rnpepl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RNPEPL1 VGNC VGNC:54353
Mus musculus RNPEPL1 MGD MGI:1914170
Rattus norvegicus RNPEPL1 RGD RGD:1595210
Bos taurus RNPEPL1 VGNC VGNC:55076
Felis catus RNPEPL1 VGNC VGNC:64712
Macaca mulatta RNPEPL1 VGNC VGNC:76712
Others RNPEPL1 NCBI