ADCK1 - aarF domain containing kinase 1 Gene

Homo sapiens

Gene ID: 57143 | Gene type: protein coding

About ADCK1

This gene has 8 transcripts (splice variants), 200 orthologues and 4 paralogues. Ubiquitous expression in brain (RPKM 2.2), thyroid (RPKM 1.9) and 25 other tissues.

Summary

Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Involved in negative regulation of mitochondrial fusion and positive regulation of cristae formation. Predicted to be located in extracellular region. Predicted to be active in mitochondrial inner membrane. Predicted to be integral component of mitochondrial membrane. [provided by Alliance of Genome Resources, Apr 2022]

ADCK1 Products(8)

mRNA	Protein	Name
NM_001142545.2	NP_001136017.1	aarF domain-containing protein kinase 1 isoform b
NM_001366485.2	NP_001353414.1	aarF domain-containing protein kinase 1 isoform c
NM_001366486.2	NP_001353415.1	aarF domain-containing protein kinase 1 isoform d
NM_001366487.2	NP_001353416.1	aarF domain-containing protein kinase 1 isoform e
NM_001366488.2	NP_001353417.1	aarF domain-containing protein kinase 1 isoform f
NM_001366489.2	NP_001353418.1	aarF domain-containing protein kinase 1 isoform g
NM_001366490.2	NP_001353419.1	aarF domain-containing protein kinase 1 isoform h
NM_020421.4	NP_065154.2	aarF domain-containing protein kinase 1 isoform a precursor

ADCK1 Protein Structure

ABC1

0
100
200
300
400
523 a.a.

Protein Preferred Names

Protein Names

aarF domain-containing protein kinase 1

Related Diseases

Diseases

Alias

Water-Clear Cell Adenoma

Coenzyme Q10 Deficiency, Primary, 4

Scar9	Spinocerebellar Ataxia, Autosomal Recessive 9
Autosomal Recessive Ataxia Due To Ubiquinone Deficiency	COQ10D4
Arca2	Autosomal Recessive Cerebellar Ataxia Type 2
Primary Coenzyme Q10 Deficiency 4	Autosomal Recessive Ataxia Due To Coenzyme Q10 Deficiency
Autosomal Recessive Spinocerebellar Ataxia Type 9	Autosomal Recessive Spinocerebellar Ataxia 9
Spinocerebellar Ataxia Autosomal Recessive 9	Coenzyme Q10 Deficiency, Primary, Type 4
Ataxia, Spinocerebellar, Autosomal Recessive, Type 9

Lipoadenoma

Parathyroid Carcinoma

Parathyroid Cancer	Parathyroid Neoplasms
Malignant Tumor Of Parathyroid Gland	PRTC
Carcinoma Of Parathyroid Gland	Malignant Neoplasm Of Parathyroid Gland
Parathyroid Gland Adenocarcinoma	Parathyroid Gland Cancer
Parathyroid Neoplasm	Parathyroid Gland Carcinoma
Malignant Neoplasm Of The Parathyroid	Neoplasm Of Parathyroid Gland
Parathyroid Gland Neoplasm	Cancer Of The Parathyroid
Cancer Of The Parathyroid Gland	Malignant Neoplasm Of Parathyroid
Malignant Parathyroid Gland Neoplasm	Malignant Parathyroid Gland Tumor
Malignant Parathyroid Neoplasm	Malignant Parathyroid Tumor
Malignant Tumor Of Parathyroid	Parathyroid Adenocarcinoma
Neoplasm Of The Parathyroid Gland	Carcinoma, Parathyroid

Coenzyme Q10 Deficiency Disease

Coenzyme Q10 Deficiency	Coq10 Deficiency
Primary Coenzyme Q10 Deficiency	Coenzyme Q Deficiency
Coq Deficiency	Primary Coq10 Deficiency
Ubiquinone Deficiency	Coenzyme Q10 Deficiency, Primary
Coq10 Deficiency, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00323	ADCK1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ADCK1	VGNC	VGNC:69472
Bos taurus	ADCK1	VGNC	VGNC:25639
Rattus norvegicus	ADCK1	RGD	RGD:1308263
Felis catus	ADCK1	VGNC	VGNC:59610
Mus musculus	ADCK1	MGD	MGI:1919363
Canis familiaris	ADCK1	VGNC	VGNC:37615

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