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ADCK1 - aarF domain containing kinase 1 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57143

About ADCK1

This gene has 8 transcripts (splice variants), 200 orthologues and 4 paralogues. Ubiquitous expression in brain (RPKM 2.2), thyroid (RPKM 1.9) and 25 other tissues.

Summary

Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Involved in negative regulation of mitochondrial fusion and positive regulation of cristae formation. Predicted to be located in extracellular region. Predicted to be active in mitochondrial inner membrane. Predicted to be integral component of mitochondrial membrane. [provided by Alliance of Genome Resources, Apr 2022]

ADCK1 Products (8)

mRNA	Protein	Name
NM_001142545.2	NP_001136017.1	aarF domain-containing protein kinase 1 isoform b
NM_001366485.2	NP_001353414.1	aarF domain-containing protein kinase 1 isoform c
NM_001366486.2	NP_001353415.1	aarF domain-containing protein kinase 1 isoform d
NM_001366487.2	NP_001353416.1	aarF domain-containing protein kinase 1 isoform e
NM_001366488.2	NP_001353417.1	aarF domain-containing protein kinase 1 isoform f
NM_001366489.2	NP_001353418.1	aarF domain-containing protein kinase 1 isoform g
NM_001366490.2	NP_001353419.1	aarF domain-containing protein kinase 1 isoform h
NM_020421.4	NP_065154.2	aarF domain-containing protein kinase 1 isoform a precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of mitochondrial fusion	IMP IMP: Inferred from mutant phenotype	31125351	GOA
involved in positive regulation of cristae formation	IMP IMP: Inferred from mutant phenotype	31125351	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	33988507	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADCK1 Protein Structure

ABC1

0
100
200
300
400
500
523 a.a.

Protein Preferred Names	Protein Names
aarF domain-containing protein kinase 1

Related Diseases

Diseases	Alias
Water-Clear Cell Adenoma
Coenzyme Q10 Deficiency, Primary, 4	Scar9 Spinocerebellar Ataxia, Autosomal Recessive 9 Autosomal Recessive Ataxia Due To Ubiquinone Deficiency COQ10D4 Arca2 Autosomal Recessive Cerebellar Ataxia Type 2 Primary Coenzyme Q10 Deficiency 4 Autosomal Recessive Ataxia Due To Coenzyme Q10 Deficiency Autosomal Recessive Spinocerebellar Ataxia Type 9 Autosomal Recessive Spinocerebellar Ataxia 9 Spinocerebellar Ataxia Autosomal Recessive 9 Coenzyme Q10 Deficiency, Primary, Type 4 Ataxia, Spinocerebellar, Autosomal Recessive, Type 9
Lipoadenoma
Parathyroid Carcinoma	Parathyroid Cancer Parathyroid Neoplasms Malignant Tumor Of Parathyroid Gland PRTC Carcinoma Of Parathyroid Gland Malignant Neoplasm Of Parathyroid Gland Parathyroid Gland Adenocarcinoma Parathyroid Gland Cancer Parathyroid Neoplasm Parathyroid Gland Carcinoma Malignant Neoplasm Of The Parathyroid Neoplasm Of Parathyroid Gland Parathyroid Gland Neoplasm Cancer Of The Parathyroid Cancer Of The Parathyroid Gland Malignant Neoplasm Of Parathyroid Malignant Parathyroid Gland Neoplasm Malignant Parathyroid Gland Tumor Malignant Parathyroid Neoplasm Malignant Parathyroid Tumor Malignant Tumor Of Parathyroid Parathyroid Adenocarcinoma Neoplasm Of The Parathyroid Gland Carcinoma, Parathyroid
Coenzyme Q10 Deficiency Disease	Coenzyme Q10 Deficiency Coq10 Deficiency Primary Coenzyme Q10 Deficiency Coenzyme Q Deficiency Coq Deficiency Primary Coq10 Deficiency Ubiquinone Deficiency Coenzyme Q10 Deficiency, Primary Coq10 Deficiency, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00323	ADCK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ADCK1	VGNC	VGNC:69472
Bos taurus	ADCK1	VGNC	VGNC:25639
Rattus norvegicus	ADCK1	RGD	RGD:1308263
Felis catus	ADCK1	VGNC	VGNC:59610
Mus musculus	ADCK1	MGD	MGI:1919363
Canis familiaris	ADCK1	VGNC	VGNC:37615
Others	ADCK1	NCBI