ACTR3B - actin related protein 3B Gene
Also Known as ARP11; ARP3BETA
Species: Homo sapiens
About ACTR3B
This gene has 5 transcripts (splice variants), 184 orthologues and 26 paralogues. Broad expression in brain (RPKM 3.7), testis (RPKM 1.9) and 25 other tissues.
Summary
This gene encodes a member of the actin-related proteins (ARP), which form multiprotein complexes and share 35-55% amino acid identity with conventional actin. The protein encoded by this gene may have a regulatory role in the actin Cytoskeleton and induce cell-shape change and motility. Pseudogenes of this gene are located on chromosomes 2, 4, 10, 16, 22 and Y. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
ACTR3B Products (9)
| mRNA | Protein | Name |
|---|---|---|
| NM_001040135.3 | NP_001035225.1 | actin-related protein 3B isoform 2 |
| NM_001350940.2 | NP_001337869.1 | actin-related protein 3B isoform 3 |
| NM_001350941.2 | NP_001337870.1 | actin-related protein 3B isoform 3 |
| NM_001350942.2 | NP_001337871.1 | actin-related protein 3B isoform 3 |
| NM_001350943.2 | NP_001337872.1 | actin-related protein 3B isoform 3 |
| NM_001350944.2 | NP_001337873.1 | actin-related protein 3B isoform 4 |
| NM_001350945.2 | NP_001337874.1 | actin-related protein 3B isoform 5 |
| NM_001350946.2 | NP_001337875.1 | actin-related protein 3B isoform 6 |
| NM_020445.6 | NP_065178.1 | actin-related protein 3B isoform 1 |
ACTR3B Protein Structure
Actin: Actin (7 - 409)
- 0
- 100
- 200
- 300
- 400
- 418 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
actin-related protein 3B |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Breast Osteosarcoma |
|
|
| Neuronopathy, Distal Hereditary Motor, Type I |
|
|
| Lissencephaly 3 |
|
|
| Brachydactyly, Type A3 |
|
|
| Lung Cancer Susceptibility 3 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | ACTR3B | VGNC | VGNC:80326 |
| Rattus norvegicus | ACTR3B | RGD | RGD:1565759 |
| Mus musculus | ACTR3B | MGD | MGI:2661120 |
| Bos taurus | ACTR3B | VGNC | VGNC:107215 |
| Canis familiaris | ACTR3B | VGNC | VGNC:49707 |
| Others | ACTR3B | NCBI |