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Tbx20 - T-box 20 Gene

Also Known as Tbx12; 9430010M06Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 57246

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including heart development; regulation of transcription by RNA polymerase II; and visceral motor neuron differentiation. Acts upstream of or within several processes, including circulatory system development; negative regulation of SMAD protein complex assembly; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Is expressed in several structures, including early conceptus; genitourinary system; heart; hindbrain; and sensory organ. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in atrial heart septal defect 4. Orthologous to human TBX20 (T-box transcription factor 20). [provided by Alliance of Genome Resources, Apr 2022]

Tbx20 Products (3)

mRNA	Protein	Name
NM_001205085.2	NP_001192014.1	T-box transcription factor TBX20 isoform c
NM_020496.4	NP_065242.1	T-box transcription factor TBX20 isoform b
NM_194263.3	NP_919239.1	T-box transcription factor TBX20 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	14978031	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	14550786	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14978031	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	14550786	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	14550786	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	14550786	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	14550786	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15843409	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in aortic valve development	IMP IMP: Inferred from mutant phenotype	15843409	MGI
involved in atrioventricular canal development	IMP IMP: Inferred from mutant phenotype	21983003	MGI
involved in atrioventricular valve development	IMP IMP: Inferred from mutant phenotype	21983003	MGI
acts upstream of or within blood circulation	IMP IMP: Inferred from mutant phenotype	15843414	MGI
acts upstream of or within branching involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	15843414	MGI
acts upstream of or within cardiac chamber formation	IMP IMP: Inferred from mutant phenotype	19661464	MGI
involved in cardiac chamber formation	IMP IMP: Inferred from mutant phenotype	15901664	MGI
involved in cardiac muscle tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	15843409	MGI
involved in cardiac right ventricle morphogenesis	IMP IMP: Inferred from mutant phenotype	15843409	MGI
involved in cardiac septum development	IMP IMP: Inferred from mutant phenotype	15843409	MGI
acts upstream of or within cell population proliferation	IMP IMP: Inferred from mutant phenotype	15843407	MGI
acts upstream of or within dorsal/ventral pattern formation	IMP IMP: Inferred from mutant phenotype	15901664	MGI
acts upstream of or within embryonic heart tube development	IGI IGI: Inferred from genetic interaction	15843414	MGI
acts upstream of or within embryonic heart tube development	IMP IMP: Inferred from mutant phenotype	15843414	MGI
involved in embryonic heart tube elongation	IMP IMP: Inferred from mutant phenotype	15901664	MGI
involved in embryonic heart tube morphogenesis	IMP IMP: Inferred from mutant phenotype	15901664	MGI
involved in endocardial cushion formation	IMP IMP: Inferred from mutant phenotype	15843409	MGI
involved in endocardial cushion morphogenesis	IMP IMP: Inferred from mutant phenotype	15901664	MGI
acts upstream of or within heart looping	IMP IMP: Inferred from mutant phenotype	15843407	MGI
involved in heart looping	IMP IMP: Inferred from mutant phenotype	15843409	MGI
involved in mesenchymal cell development	IMP IMP: Inferred from mutant phenotype	21983003	MGI
acts upstream of or within motor neuron migration	IMP IMP: Inferred from mutant phenotype	17119020	MGI
acts upstream of or within muscle contraction	IMP IMP: Inferred from mutant phenotype	15843414	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14978031	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15843409	MGI
acts upstream of or within negative regulation of SMAD protein signal transduction	IDA IDA: Inferred from direct assay	19661464	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	19661464	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15901664	MGI
involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	15843409	MGI
involved in outflow tract septum morphogenesis	IMP IMP: Inferred from mutant phenotype	15843409	MGI
involved in pericardium morphogenesis	IMP IMP: Inferred from mutant phenotype	15901664	MGI
acts upstream of positive regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	21983003	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15843407	MGI
involved in positive regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	15901664	MGI
involved in positive regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	21983003	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14550786	MGI
involved in pulmonary valve formation	IMP IMP: Inferred from mutant phenotype	15843409	MGI
involved in tricuspid valve development	IMP IMP: Inferred from mutant phenotype	15843409	MGI
involved in visceral motor neuron differentiation	IMP IMP: Inferred from mutant phenotype	15843409	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	14550786	MGI
located in nucleus	IDA IDA: Inferred from direct assay	14550786	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
T-box transcription factor TBX20	T-box protein 20

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14276	TBX20 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tbx20	NCBI	NCBI:57057