Terf2ip - telomeric repeat binding factor 2, interacting protein Gene

Mus musculus

Also known as Rap1

Gene ID: 57321 | Gene type: protein coding

About Terf2ip

Summary

Enables telomeric DNA binding activity. Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling; regulation of nucleobase-containing compound metabolic process; and telomere maintenance via telomere lengthening. Located in chromosome, telomeric region; cytoplasm; and nucleus. Is expressed in embryo. Orthologous to human TERF2IP (TERF2 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]

Terf2ip Products(1)

mRNA	Protein	Name
NM_020584.2	NP_065609.2	telomeric repeat-binding factor 2-interacting protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20339076	MGI
enables telomeric DNA binding	IDA IDA: Inferred from direct assay	23685356	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA recombination at telomere	IMP IMP: Inferred from mutant phenotype	20339076	MGI
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	20622870	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	20622870	MGI
NOT involved in protection from non-homologous end joining at telomere	IMP IMP: Inferred from mutant phenotype	20339076	MGI
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20622869	MGI
involved in regulation of double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	20339076	MGI
involved in telomere maintenance via telomere lengthening	IMP IMP: Inferred from mutant phenotype	20339076	MGI
NOT involved in telomeric loop formation	IMP IMP: Inferred from mutant phenotype	24120135	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	15109494	MGI
located in chromosome, telomeric region	IMP IMP: Inferred from mutant phenotype	20622869	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	20622870	MGI
located in male germ cell nucleus	IDA IDA: Inferred from direct assay	24062341	MGI
located in nucleus	IDA IDA: Inferred from direct assay	20622870	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

telomeric repeat-binding factor 2-interacting protein 1

RAP1 homolog	TERF2-interacting telomeric protein 1
TRF2-interacting telomeric protein 1	TRF2-interacting telomeric protein Rap1
repressor/activator protein 1 homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14374	TERF2IP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Terf2ip	NCBI	NCBI:54386

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