MIR20B - microRNA 20b Gene

Homo sapiens

Also known as MIRN20B; mir-20b; hsa-mir-20b

Gene ID: 574032 | Gene type: ncRNA

About MIR20B

Cytogenetic location: Xq26.2 Genomic coordinates (GRCh38): X:134,169,809-134,169,877 (from NCBI)

This gene has 1 transcript (splice variant), 45 orthologues and 4 paralogues.

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	21042576	GOA
enables mRNA base-pairing translational repressor activity	IDA IDA: Inferred from direct assay	17205120	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	28595801	GOA
involved in miRNA-mediated gene silencing by mRNA destabilization	IDA IDA: Inferred from direct assay	32336590	GOA
involved in miRNA-mediated post-transcriptional gene silencing	IDA IDA: Inferred from direct assay	17205120	GOA
involved in negative regulation of angiogenesis	IDA IDA: Inferred from direct assay	24048733	GOA
involved in negative regulation of vascular endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	28595801	GOA
involved in positive regulation of cellular senescence	IMP IMP: Inferred from mutant phenotype	28595801	GOA
acts upstream of positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21042576	GOA
acts upstream of positive regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	21042576	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	26646931	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Diseases

Diseases

Alias

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Kidney Cancer

Renal Cancer	Renal Carcinoma
Kidney Neoplasm	Malignant Neoplasm Of Kidney Except Pelvis
Malignant Tumour Of Kidney	Kidney Neoplasms
Cancer, Kidney	Cancer, Renal
Malignant Neoplasm Of Kidney	Renal Cell Carcinoma

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Gastric Fundus Cancer

Gastric Fundus Carcinoma	Ca Fundus - Stomach
Malignant Neoplasm Of Fundus Of Stomach	Malignant Tumor Of Fundus Of Stomach
Cancer Of Fundus Of Stomach	Carcinoma Of Fundus Of Stomach
Malignant Neoplasm Of Gastric Fundus

Retinal Vascular Disease

Retinal Vascular	Retinal Vascular Disorder
Retina Circulation Disorder

Extracranial Neuroblastoma

Microvascular Complications Of Diabetes 5

Diabetic Retinopathy	Microvascular Complications Of Diabetes, Susceptibility To, 5
MVCD5	Retinopathy, Diabetic
Diabetic Nephropathy	Retinopathy, Diabetic, Susceptibility To
Retinal Abnormality - Diabetes-Related

Central Nervous System Cancer

Central Nervous System Tumor	Central Nervous System Tumors
Cns Neoplasm	Malignant Neoplasm Of Central Nervous System
Malignant Tumor Of Cns	Neoplasm Of Central Nervous System
Malignant Neoplasm Of The Central Nervous System	Neoplasm Of The Central Nervous System
Central Nervous System Neoplasms	Central Nervous System Neoplasm

Malignant Astrocytoma

Astrocytic Tumor	Astrocytoma Of Brain
Astrocytoma Of Cerebrum	Astroglioma
Cerebral Astrocytoma	Astrocytoma

Mature B-Cell Neoplasm

Mature B-Cell Lymphocytic Neoplasm	Neoplasm Of Mature B-Cells
Mature B-Cell Non-Hodgkin Neoplasm With Leukaemic Behaviour

Retinal Disease

Retinal Diseases	Retinal Disorder
Retinal Disorders

Spinal Disease

Spinal Disorder

Spinal Diseases

Connective Tissue Cancer

Neoplasms, Connective Tissue	Connective Tissue Neoplasm
Mesenchymal Tissue Malignant Neoplasm	Neoplasm Of Connective Tissues
Tumour Of Connective Tissue

Sensory System Disease

Lymphatic System Cancer

Bone Cancer

Malignant Bone Neoplasm	Bone Carcinoma
Bone Neoplasms	Bone Neoplasm
Bone Tumour	Ca - Bone Cancer
Malignant Bone Tumour	Malignant Neoplasm Of Bone
Malignant Osseous Tumor	Neoplasm Of Bone
Osseous Tumor	Osteosarcoma Of Bone
Osteogenic Neoplasm

Lymphatic System Disease

Lymphatic Diseases	Adenopathy
Lymphatic Disease	Disease Of Lympoid System
Disorder Of Lymph Node And Lymphatics	Disorder Of Lymphatic System
Disorder Of Lymphoid System	Lymphangiopathy
Lymphatic Disorder	Lympoid System Disease
Abnormality Of The Lymphatic System

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Central Nervous System Disease

Cns Disorder	CNS
Cns Diseases	Central Nervous System Diseases

Immune System Disease

Abnormality Of The Immune System	Immune System And Disorders
Immune System Diseases

Plasma Cell Neoplasm

Plasma Cell Dyscrasia	Paraproteinemias
Plasma Cell Tumour	Plasmacytic Tumor
Multiple Myeloma	Plasmacytoma
Plasma Cell Tumours	Plasma Cells Dyscrasia

Eye Disease

Eye Diseases	Abnormality Of The Eye
Toxoplasma Oculopathy

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma	Lymphoma, Non-Hodgkin
NHL	Lymphoma, Non-Hodgkin, Somatic
Lymphoma, Follicular, Somatic	Familial Non-Hodgkin Lymphoma
Lymphoma Non-Hodgkins	Follicular Lymphoma, Somatic
Lymphosarcoma	Non-Hodgkins Lymphoma

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RI00428	hsa-miR-20b-5p inhibitor	92.46%	Unkown
HY-R00428	hsa-miR-20b-5p mimic	93.37%	Unkown
HY-R00427	hsa-miR-20b-3p mimic	/	Unkown
HY-R00427A	hsa-miR-20b-3p agomir	/	Unkown
HY-R00428A	hsa-miR-20b-5p agomir	/	Unkown
HY-R02821	mmu-miR-20b-3p mimic	/	Unkown
HY-R02821A	mmu-miR-20b-3p agomir	/	Unkown
HY-R04299	rno-miR-20b-3p mimic	/	Unkown
HY-R04299A	rno-miR-20b-3p agomir	/	Unkown
HY-RI00427	hsa-miR-20b-3p inhibitor	/	Unkown
HY-RI00427A	hsa-miR-20b-3p antagomir	/	Unkown
HY-RI00428A	hsa-miR-20b-5p antagomir	/	Unkown
HY-RI02821	mmu-miR-20b-3p inhibitor	/	Unkown
HY-RI02821A	mmu-miR-20b-3p antagomir	/	Unkown
HY-RI04299	rno-miR-20b-3p inhibitor	/	Unkown
HY-RI04299A	rno-miR-20b-3p antagomir	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MIR20B	MGD	MGI:3618748
Rattus norvegicus	MIR20B	RGD	RGD:2325420

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