MIR503 - microRNA 503 Gene

Also Known as MIRN503; mir-503; hsa-mir-503

Species: Homo sapiens

Gene Type: ncRNA

Gene ID: 574506

About MIR503

Cytogenetic location: Xq26.3 Genomic coordinates (GRCh38): X:134,546,328-134,546,398 (from NCBI)

This gene has 1 transcript (splice variant).

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables mRNA base-pairing translational repressor activity	IDA IDA: Inferred from direct assay	21220732	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in miRNA-mediated gene silencing by inhibition of translation	IDA IDA: Inferred from direct assay	21220732	GOA
involved in miRNA-mediated post-transcriptional gene silencing	IDA IDA: Inferred from direct assay	21220732	GOA
involved in negative regulation of ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	23263626	GOA
involved in negative regulation of G0 to G1 transition	IGI IGI: Inferred from genetic interaction	23263626	GOA
involved in negative regulation of angiogenesis	IGI IGI: Inferred from genetic interaction	28566713	GOA
involved in negative regulation of blood vessel endothelial cell migration	IGI IGI: Inferred from genetic interaction	23263626	GOA
involved in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IDA IDA: Inferred from direct assay	21220732	GOA
involved in negative regulation of cell cycle G1/S phase transition	IDA IDA: Inferred from direct assay	21220732	GOA
involved in negative regulation of cell migration involved in sprouting angiogenesis	IGI IGI: Inferred from genetic interaction	28566713	GOA
involved in negative regulation of cell-substrate adhesion	IDA IDA: Inferred from direct assay	21220732	GOA
involved in negative regulation of endothelial cell migration	IDA IDA: Inferred from direct assay	21220732	GOA
involved in negative regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	21220732	GOA
involved in negative regulation of fibroblast growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	23263626	GOA
involved in negative regulation of vascular associated smooth muscle cell migration	IDA IDA: Inferred from direct assay	21220732	GOA
involved in negative regulation of vascular associated smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	21220732	GOA
involved in negative regulation of vascular associated smooth muscle cell proliferation	IGI IGI: Inferred from genetic interaction	23263626	GOA
involved in negative regulation of vascular endothelial cell proliferation	IGI IGI: Inferred from genetic interaction	23263626	GOA
involved in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IGI IGI: Inferred from genetic interaction	26268439	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endothelial microparticle	IDA IDA: Inferred from direct assay	26268439	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Diseases

Diseases	Alias
Adrenal Cortical Carcinoma	Adrenocortical Carcinoma Adrenal Cortex Carcinoma Carcinoma Of The Adrenal Cortex Acc Adrenocortical Cancer Carcinoma Adrenocortical
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Bone Resorption Disease	Bone Resorption
Bone Remodeling Disease
Tongue Disease	Abnormality Of The Tongue Tongue Diseases Tongue Disorders Disorder Of Tongue Glossopathy Unspecified Condition Of The Tongue
Oral Cavity Cancer	Malignant Neoplasm Of Floor Of Mouth Oral Cavity Carcinoma Malignant Neoplasm Of Mouth
Tongue Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Tongue
Thoracic Cancer	Thoracic Tumor Thorax Cancer Thorax Neoplasm Tumor Of Thorax Thoracic Neoplasms
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Respiratory System Cancer
Cervix Disease	Uterine Cervical Diseases Cervix Disorders Cervix Diseases
Large Intestine Cancer
Respiratory System Disease	Abnormality Of The Respiratory System Respiration Disorders Respiratory Tract Diseases
Oral Squamous Cell Carcinoma	Mouth Squamous Cell Carcinoma Squamous Cell Carcinoma Of Mouth
Head And Neck Cancer	Head And Neck Neoplasm Head And Neck Tumours Head/Neck Neoplasm Tumor Of Head And Neck Head And Neck Neoplasms Hnc Cancer, Head/Neck
Malignant Astrocytoma	Astrocytic Tumor Astrocytoma Of Brain Astrocytoma Of Cerebrum Astroglioma Cerebral Astrocytoma Astrocytoma
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RI01514A	hsa-miR-503-5p antagomir	97.54%	Unkown
HY-RI01514	hsa-miR-503-5p inhibitor	98.20%	Unkown
HY-R01514	hsa-miR-503-5p mimic	92.20%	Unkown
HY-R01514A	hsa-miR-503-5p agomir	95.37%	Unkown
HY-R03236	mmu-miR-503-3p mimic	96.51%	Unkown
HY-R01513	hsa-miR-503-3p mimic	/	Unkown
HY-R01513A	hsa-miR-503-3p agomir	/	Unkown
HY-R03236A	mmu-miR-503-3p agomir	/	Unkown
HY-R03237	mmu-miR-503-5p mimic	/	Unkown
HY-R03237A	mmu-miR-503-5p agomir	/	Unkown
HY-R04501	rno-miR-503-3p mimic	/	Unkown
HY-R04501A	rno-miR-503-3p agomir	/	Unkown
HY-RI01513	hsa-miR-503-3p inhibitor	/	Unkown
HY-RI01513A	hsa-miR-503-3p antagomir	/	Unkown
HY-RI03236	mmu-miR-503-3p inhibitor	/	Unkown
HY-RI03236A	mmu-miR-503-3p antagomir	/	Unkown
HY-RI03237	mmu-miR-503-5p inhibitor	/	Unkown
HY-RI03237A	mmu-miR-503-5p antagomir	/	Unkown
HY-RI04501	rno-miR-503-3p inhibitor	/	Unkown
HY-RI04501A	rno-miR-503-3p antagomir	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MIR503	MGD	MGI:3619428
Rattus norvegicus	MIR503	RGD	RGD:2325516