MIR503 - microRNA 503 Gene

Homo sapiens

Also known as MIRN503; mir-503; hsa-mir-503

Gene ID: 574506 | Gene type: ncRNA

About MIR503

Cytogenetic location: Xq26.3 Genomic coordinates (GRCh38): X:134,546,328-134,546,398 (from NCBI)

This gene has 1 transcript (splice variant).

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA base-pairing translational repressor activity	IDA IDA: Inferred from direct assay	21220732	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in miRNA-mediated gene silencing by inhibition of translation	IDA IDA: Inferred from direct assay	21220732	GOA
involved in miRNA-mediated post-transcriptional gene silencing	IDA IDA: Inferred from direct assay	21220732	GOA
involved in negative regulation of ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	23263626	GOA
involved in negative regulation of G0 to G1 transition	IGI IGI: Inferred from genetic interaction	23263626	GOA
involved in negative regulation of angiogenesis	IGI IGI: Inferred from genetic interaction	28566713	GOA
involved in negative regulation of blood vessel endothelial cell migration	IGI IGI: Inferred from genetic interaction	23263626	GOA
involved in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IDA IDA: Inferred from direct assay	21220732	GOA
involved in negative regulation of cell cycle G1/S phase transition	IDA IDA: Inferred from direct assay	21220732	GOA
involved in negative regulation of cell migration involved in sprouting angiogenesis	IGI IGI: Inferred from genetic interaction	28566713	GOA
involved in negative regulation of cell-substrate adhesion	IDA IDA: Inferred from direct assay	21220732	GOA
involved in negative regulation of endothelial cell migration	IDA IDA: Inferred from direct assay	21220732	GOA
involved in negative regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	21220732	GOA
involved in negative regulation of fibroblast growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	23263626	GOA
involved in negative regulation of vascular associated smooth muscle cell migration	IDA IDA: Inferred from direct assay	21220732	GOA
involved in negative regulation of vascular associated smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	21220732	GOA
involved in negative regulation of vascular associated smooth muscle cell proliferation	IGI IGI: Inferred from genetic interaction	23263626	GOA
involved in negative regulation of vascular endothelial cell proliferation	IGI IGI: Inferred from genetic interaction	23263626	GOA
involved in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IGI IGI: Inferred from genetic interaction	26268439	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endothelial microparticle	IDA IDA: Inferred from direct assay	26268439	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Diseases

Diseases

Alias

Adrenal Cortical Carcinoma

Adrenocortical Carcinoma	Adrenal Cortex Carcinoma
Carcinoma Of The Adrenal Cortex	Acc
Adrenocortical Cancer	Carcinoma Adrenocortical

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Bone Resorption Disease

Bone Resorption

Bone Remodeling Disease

Tongue Disease

Abnormality Of The Tongue	Tongue Diseases
Tongue Disorders	Disorder Of Tongue
Glossopathy	Unspecified Condition Of The Tongue

Oral Cavity Cancer

Malignant Neoplasm Of Floor Of Mouth	Oral Cavity Carcinoma
Malignant Neoplasm Of Mouth

Tongue Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Tongue

Thoracic Cancer

Thoracic Tumor	Thorax Cancer
Thorax Neoplasm	Tumor Of Thorax
Thoracic Neoplasms

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Respiratory System Cancer

Cervix Disease

Uterine Cervical Diseases	Cervix Disorders
Cervix Diseases

Large Intestine Cancer

Respiratory System Disease

Abnormality Of The Respiratory System	Respiration Disorders
Respiratory Tract Diseases

Oral Squamous Cell Carcinoma

Mouth Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Mouth

Head And Neck Cancer

Head And Neck Neoplasm	Head And Neck Tumours
Head/Neck Neoplasm	Tumor Of Head And Neck
Head And Neck Neoplasms	Hnc
Cancer, Head/Neck

Malignant Astrocytoma

Astrocytic Tumor	Astrocytoma Of Brain
Astrocytoma Of Cerebrum	Astroglioma
Cerebral Astrocytoma	Astrocytoma

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RI01514A	hsa-miR-503-5p antagomir	97.54%	Unkown
HY-R01514	hsa-miR-503-5p mimic	92.20%	Unkown
HY-R01514A	hsa-miR-503-5p agomir	95.37%	Unkown
HY-R03236	mmu-miR-503-3p mimic	96.51%	Unkown
HY-RI01514	hsa-miR-503-5p inhibitor	90.07%	Unkown
HY-R01513	hsa-miR-503-3p mimic	/	Unkown
HY-R01513A	hsa-miR-503-3p agomir	/	Unkown
HY-R03236A	mmu-miR-503-3p agomir	/	Unkown
HY-R03237	mmu-miR-503-5p mimic	/	Unkown
HY-R03237A	mmu-miR-503-5p agomir	/	Unkown
HY-R04501	rno-miR-503-3p mimic	/	Unkown
HY-R04501A	rno-miR-503-3p agomir	/	Unkown
HY-RI01513	hsa-miR-503-3p inhibitor	/	Unkown
HY-RI01513A	hsa-miR-503-3p antagomir	/	Unkown
HY-RI03236	mmu-miR-503-3p inhibitor	/	Unkown
HY-RI03236A	mmu-miR-503-3p antagomir	/	Unkown
HY-RI03237	mmu-miR-503-5p inhibitor	/	Unkown
HY-RI03237A	mmu-miR-503-5p antagomir	/	Unkown
HY-RI04501	rno-miR-503-3p inhibitor	/	Unkown
HY-RI04501A	rno-miR-503-3p antagomir	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MIR503	MGD	MGI:3619428
Rattus norvegicus	MIR503	RGD	RGD:2325516

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